Skip to main content

Table 4 Causal coefficients from MR analysis

From: Association of serum 25-hydroxyvitamin D with metabolic syndrome and type 2 diabetes: a one sample Mendelian randomization study

GRSs

OR (95%CI)

for MS

P

OR (95%CI)

for T2D

P

OR (95%CI)

for abnormal SBP

P

OR (95%CI)

for abnormal DBP

P

GRSsynthesis

 ORZY [per 1 unit higher in GRS]

1.21(0.88–1.66)

0.497

1.07(1.01–1.42)

0.048*

1.35(0.85–1.84)

0.435

1.16(1.02–1.65)

0.003*

 ORIV [per 25 nmol/L decrease 25(OH) D concentration]

0.85(0.56–1.28)

0.586

1.10(1.02–1.45)

0.014*

0.76(0.51–1.31)

0.141

1.14(1.03–1.43)

0.019*

GRSmetabolism

 ORZY [per 1 unit higher in GRS]

1.06(0.79–1.44)

0.337

0.97(0.66–1.43)

0.646

0.92(0.73–1.17)

0.652

1.13(0.86–1.48)

0.627

 ORIV [per 25 nmol/L decrease 25(OH) D concentration]

0.92(0.69–1.22)

0.159

0.91(0.60–1.36)

0.742

1.04(0.74–1.45)

0.371

0.83(0.62–1.10)

0.579

GRScombined

 ORZY [per 1 unit higher in GRS]

1.05(0.83–1.32)

0.224

1.16(0.67–1.51)

0.154

0.79(0.60–1.02)

0.743

1.03(0.73–1.15)

0.085

 ORIV [per 25 nmol/L decrease 25(OH) D concentration]

1.04(0.70–1.53)

0.457

0.92(0.70–1.02)

0.082

0.88(0.67–1.15)

0.628

1.05(1.00–1.49)

0.046*

  1. Adjusted for age at interview, BMI, WHR, income, smoking status, alcohol consumption status, physical activity and familial history of diabetes. *: P < 0.05
  2. The association of T2D, MS, and abnormal SBP and DBP with vitamin D-determined GRSs are shown