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Table 4 Causal coefficients from MR analysis

From: Association of serum 25-hydroxyvitamin D with metabolic syndrome and type 2 diabetes: a one sample Mendelian randomization study

GRSs OR (95%CI)
for MS
P OR (95%CI)
for T2D
P OR (95%CI)
for abnormal SBP
P OR (95%CI)
for abnormal DBP
P
GRSsynthesis
 ORZY [per 1 unit higher in GRS] 1.21(0.88–1.66) 0.497 1.07(1.01–1.42) 0.048* 1.35(0.85–1.84) 0.435 1.16(1.02–1.65) 0.003*
 ORIV [per 25 nmol/L decrease 25(OH) D concentration] 0.85(0.56–1.28) 0.586 1.10(1.02–1.45) 0.014* 0.76(0.51–1.31) 0.141 1.14(1.03–1.43) 0.019*
GRSmetabolism
 ORZY [per 1 unit higher in GRS] 1.06(0.79–1.44) 0.337 0.97(0.66–1.43) 0.646 0.92(0.73–1.17) 0.652 1.13(0.86–1.48) 0.627
 ORIV [per 25 nmol/L decrease 25(OH) D concentration] 0.92(0.69–1.22) 0.159 0.91(0.60–1.36) 0.742 1.04(0.74–1.45) 0.371 0.83(0.62–1.10) 0.579
GRScombined
 ORZY [per 1 unit higher in GRS] 1.05(0.83–1.32) 0.224 1.16(0.67–1.51) 0.154 0.79(0.60–1.02) 0.743 1.03(0.73–1.15) 0.085
 ORIV [per 25 nmol/L decrease 25(OH) D concentration] 1.04(0.70–1.53) 0.457 0.92(0.70–1.02) 0.082 0.88(0.67–1.15) 0.628 1.05(1.00–1.49) 0.046*
  1. Adjusted for age at interview, BMI, WHR, income, smoking status, alcohol consumption status, physical activity and familial history of diabetes. *: P < 0.05
  2. The association of T2D, MS, and abnormal SBP and DBP with vitamin D-determined GRSs are shown