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Table 3 Association of T2D and MS with serum 25 (OH) D concentration

From: Association of serum 25-hydroxyvitamin D with metabolic syndrome and type 2 diabetes: a one sample Mendelian randomization study

  MS cases
n (%)
ORXY (95%CI)1 P T2D cases
n (%)
ORXY (95%CI) 2 P
Every decreasing 10 nmol/L 25(OH)D 746(31.17) 1.10(1.02–1.23) 0.027* 361(15.09) 1.07(1.01–1.21) 0.018*
Adj-R2   0.732    0.756  
Every decreasing 25 nmol/L 25(OH)D   1.23(1.06–1.52) 0.002*   1.14(1.05–1.33) 0.001*
Adj-R2   0.789    0.764  
Quintiles of 25(OH) D (nmol/L)
 Q1(≥57.5) 135(26.68) 1.00   53(11.08) 1.00  
 Q2(46.0–57.4) 129(28.48) 1.09(1.01–1.45) 0.025* 64(13.77) 1.12(1.03–1.59) 0.004*
 Q3((36.8–45.9) 161(31.69) 1.29(1.03–1.75) < 0.001* 75(15.14) 1.33(1.05–1.67) < 0.001*
 Q4(28.5–36.7) 167(34.08) 1.47(1.17–1.81) < 0.001* 82(17.13) 1.50(1.17–1.82) < 0.001*
 Q5(< 28.4) 154(35.32) 1.55(1.24–1.89) < 0.001* 87(18.29) 1.53(1.21–1.87) < 0.001*
Adj-R2   0.784    0.753  
Clinical categories of 25(OH) D (nmol/L)
  ≥ 75 21(26.12) 1.00   10(12.44) 1.00  
 50–75 196(27.90) 1.30(1.06–1.61) 0.008* 92(13.08) 1.32(1.08–1.64) 0.001*
 25–50 390(31.90) 1.50(1.24–1.79) < 0.001* 188(15.41) 1.47(1.12–1.80) < 0.001*
  < 25 139(35.91) 1.52(1.29–1.85) < 0.001* 71(18.25) 1.54(1.27–1.85) < 0.001*
Adj-R2   0.713    0.762  
  1. 1adjusted for age at interview, BMI, WHR, income, smoking status, alcohol consumption status, physical activity, and familial history of MS; 2adjusted for age at interview, BMI WHR, income, alcohol consumption status, physical activity, and familial history of diabetes. *: P < 0.05