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Table 3 Association of T2D and MS with serum 25 (OH) D concentration

From: Association of serum 25-hydroxyvitamin D with metabolic syndrome and type 2 diabetes: a one sample Mendelian randomization study

 

MS cases

n (%)

ORXY (95%CI)1

P

T2D cases

n (%)

ORXY (95%CI) 2

P

Every decreasing 10 nmol/L 25(OH)D

746(31.17)

1.10(1.02–1.23)

0.027*

361(15.09)

1.07(1.01–1.21)

0.018*

Adj-R2

 

0.732

  

0.756

 

Every decreasing 25 nmol/L 25(OH)D

 

1.23(1.06–1.52)

0.002*

 

1.14(1.05–1.33)

0.001*

Adj-R2

 

0.789

  

0.764

 

Quintiles of 25(OH) D (nmol/L)

 Q1(≥57.5)

135(26.68)

1.00

 

53(11.08)

1.00

 

 Q2(46.0–57.4)

129(28.48)

1.09(1.01–1.45)

0.025*

64(13.77)

1.12(1.03–1.59)

0.004*

 Q3((36.8–45.9)

161(31.69)

1.29(1.03–1.75)

< 0.001*

75(15.14)

1.33(1.05–1.67)

< 0.001*

 Q4(28.5–36.7)

167(34.08)

1.47(1.17–1.81)

< 0.001*

82(17.13)

1.50(1.17–1.82)

< 0.001*

 Q5(< 28.4)

154(35.32)

1.55(1.24–1.89)

< 0.001*

87(18.29)

1.53(1.21–1.87)

< 0.001*

Adj-R2

 

0.784

  

0.753

 

Clinical categories of 25(OH) D (nmol/L)

  ≥ 75

21(26.12)

1.00

 

10(12.44)

1.00

 

 50–75

196(27.90)

1.30(1.06–1.61)

0.008*

92(13.08)

1.32(1.08–1.64)

0.001*

 25–50

390(31.90)

1.50(1.24–1.79)

< 0.001*

188(15.41)

1.47(1.12–1.80)

< 0.001*

  < 25

139(35.91)

1.52(1.29–1.85)

< 0.001*

71(18.25)

1.54(1.27–1.85)

< 0.001*

Adj-R2

 

0.713

  

0.762

 
  1. 1adjusted for age at interview, BMI, WHR, income, smoking status, alcohol consumption status, physical activity, and familial history of MS; 2adjusted for age at interview, BMI WHR, income, alcohol consumption status, physical activity, and familial history of diabetes. *: P < 0.05