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Table 3 Reclassification Statistics (95% CI) for post-stroke cognitive impairment by plasma sST2 Among Participants

From: Soluble ST2 and risk of cognitive impairment after acute ischemic stroke: a prospective observational study

 

C statistic

Calibration statistic

NRI (Continuous)

IDI

Estimate (95% CI)

p value

χ2

p value

Estimate (95% CI), %

p value

Estimate (95% CI), %

p value

Cognitive impairment: MoCA

 Conventional model

0.678 (0.640 to 0.715)

 

6.12

0.63

Reference

 

Reference

 

 Conventional model + sST2 (quartiles)

0.691 (0.653 to 0.727)

0.07

11.10

0.20

18.5 (3.0 to 33.9)

< 0.01

1.6 (0.6 to 2.6)

< 0.01

Cognitive impairment: MMSE

 Conventional model

0.672 (0.633 to 0.708)

 

1.42

0.99

Reference

 

Reference

 

 Conventional model + sST2 (quartiles)

0.683 (0.644 to 0.719)

0.11

5.19

0.74

17.8 (2.1 to 33.4)

< 0.01

1.0 (0.2 to 1.8)

< 0.01

  1. MoCA score of < 23 or MMSE score of < 27 indicates cognitive impairment
  2. Conventional model included age, sex, education level, systolic blood pressure, baseline National Institutes of Health Stroke Scale score, baseline modified Rankin Scale score, hypertension, diabetes mellitus, ischemic stroke subtype, hsCRP, anticoagulant treatment and hypoglycemic treatment
  3. Abbreviations: sST2 soluble suppression of tumorigenicity 2, CI confidence interval, IDI integrated discrimination index, MoCA Montreal Cognitive Assessment, NRI net reclassification improvement