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Table 3 Reclassification Statistics (95% CI) for post-stroke cognitive impairment by plasma sST2 Among Participants

From: Soluble ST2 and risk of cognitive impairment after acute ischemic stroke: a prospective observational study

  C statistic Calibration statistic NRI (Continuous) IDI
Estimate (95% CI) p value χ2 p value Estimate (95% CI), % p value Estimate (95% CI), % p value
Cognitive impairment: MoCA
 Conventional model 0.678 (0.640 to 0.715)   6.12 0.63 Reference   Reference  
 Conventional model + sST2 (quartiles) 0.691 (0.653 to 0.727) 0.07 11.10 0.20 18.5 (3.0 to 33.9) < 0.01 1.6 (0.6 to 2.6) < 0.01
Cognitive impairment: MMSE
 Conventional model 0.672 (0.633 to 0.708)   1.42 0.99 Reference   Reference  
 Conventional model + sST2 (quartiles) 0.683 (0.644 to 0.719) 0.11 5.19 0.74 17.8 (2.1 to 33.4) < 0.01 1.0 (0.2 to 1.8) < 0.01
  1. MoCA score of < 23 or MMSE score of < 27 indicates cognitive impairment
  2. Conventional model included age, sex, education level, systolic blood pressure, baseline National Institutes of Health Stroke Scale score, baseline modified Rankin Scale score, hypertension, diabetes mellitus, ischemic stroke subtype, hsCRP, anticoagulant treatment and hypoglycemic treatment
  3. Abbreviations: sST2 soluble suppression of tumorigenicity 2, CI confidence interval, IDI integrated discrimination index, MoCA Montreal Cognitive Assessment, NRI net reclassification improvement