Skip to main content

Table 1 Baseline Characteristics of Participants According to Plasma soluble ST2 (sST2) quartiles

From: Soluble ST2 and risk of cognitive impairment after acute ischemic stroke: a prospective observational study

Characteristicsa sST2, pg/mL p trend
< 117.60 117.60–163.51 163.51–238.77 ≥238.77
No. of subjects 155 (25.0) 154 (24.9) 156 (25.2) 154 (24.9)  
Demographic features
 Age, y 58.5 ± 10.3 59.9 ± 9.6 59.2 ± 10.3 62.5 ± 11.2 0.003
 Male sex, n (%) 88 (56.8) 102 (66.2) 121 (77.6) 123 (79.9) < 0.001
 Education, n (%)
  Illiteracy 8 (5.2) 15 (9.7) 10 (6.4) 18 (11.7) 0.10
  Primary 61 (39.4) 64 (41.6) 53 (34.0) 56 (36.4) 0.34
  High school 75 (48.4) 68 (44.2) 80 (51.3) 72 (46.8) 0.90
  College or higher 11 (7.1) 7 (4.6) 13 (8.3) 8 (5.2) 0.83
 Current cigarette smoking, n (%) 55 (35.5) 56 (36.4) 61 (36.5) 53 (34.4) 0.67
 Current alcohol drinking, n (%) 51 (32.9) 52 (33.8) 57 (36.4) 53 (34.9) 0.63
Clinical features
 Time from onset to randomization, h 12.0 (5.0–24.0) 12.0 (5.0–24.0) 12.0 (6.0–24.0) 6.6 (4.0–24.0) 0.02
 Baseline systolic BP, mm Hg 168.3 ± 17.5 166.0 ± 15.2 166.6 ± 16.6 169.0 ± 17.2 0.64
 Baseline diastolic BP, mm Hg 98.5 ± 9.6 97.8 ± 9.7 98.2 ± 9.4 98.6 ± 11.4 0.85
 Baseline NIHSS score 4.0 (3.0–7.0) 4.0 (2.0–6.0) 4.0 (2.0–7.0) 6.0 (3.0–9.0) < 0.001
 Baseline modified Rankin Scale score 3.0 (2.0–3.0) 3.0 (2.0–4.0) 3.0 (1.0–3.0) 3.0 (2.0–4.0) < 0.001
 High-sensitive C-reactive protein, mg/L 1.3 (0.6–3.7) 1.8 (0.7–4.9) 2.1 (0.9–4.5) 3.8 (1.4–10.0) < 0.001
Medical history, n (%)
 Hypertension 122 (78.7) 120 (77.9) 123 (78.9) 111 (72.1) 0.21
 Hyperlipidemia 14 (9.0) 10 (6.5) 8 (5.1) 10 (6.5) 0.32
 Diabetes mellitus 30 (19.4) 23 (15.0) 30 (19.2) 21 (13.6) 0.34
 Coronary heart disease 12 (7.7) 20 (13.0) 16 (10.3) 18 (11.7) 0.41
 Family history of stroke 33 (21.3) 22 (14.3) 22 (14.1) 24 (15.6) 0.19
 Use of antihypertensive drugs 75 (48.4) 70 (45.5) 67 (43.0) 58 (37.7) 0.05
 Ischemic stroke subtype, n (%)
  Thrombotic 101 (65.2) 101 (65.6) 105 (67.3) 95 (61.7) 0.61
  Embolic 4 (2.6) 5 (3.3) 5 (3.2) 9 (5.8) 0.15
  Lacunar 50 (32.3) 48 (31.2) 46 (29.5) 50 (32.5) 0.95
 Receiving immediate BP reduction 67 (43.2) 81 (47.4) 83 (53.2) 72 (46.8) 0.53
 Anticoagulant treatment 35 (22.6) 32 (20.8) 36 (23.1) 48 (31.2) 0.07
 Hypoglycemic treatment 23 (14.8) 28 (18.2) 32 (20.5) 22 (14.3) 0.96
  1. Abbreviations: BP blood pressure, NIHSS National Institute of Health Stroke Scale
  2. aContinuous variables are expressed as mean ± standard deviation or median (interquartile range). Categorical variables are expressed as frequency (%)