Fig. 4

Study assessments timepoints. Patients will be randomized into 2 arms after completion of the G8 screening phase; Arm A; will be evaluated by Comprehensive Geriatric Assessment (CGA) at baseline and would be re-evaluated after every 6 months and If necessary, an onco-geriatric follow-up will be carried out. Arm B is the Control group, no geriatric visit is scheduled. Both arms will be evaluated for their quality of life using EORTC – QLQ-C30 questionnaire every 3 months. Blood samples from patients will be collected to evaluate T cells senescence and myeloid-derived suppressor cells at baseline and after 12 months or at disease progression