| |
Non-hip fracture
|
Hip fracture
|
Hazard ratio (95% confidence interval)
|
|---|
|
Event
|
PY
|
IR
|
Event
|
PY
|
IR
|
Crude
|
Adjusted
|
|---|
|
Overall
|
35
|
7733
|
0.5
|
59
|
7262
|
0.8
|
1.71 (1.12–2.59)*
|
1.62 (1.05–2.49)*
|
|
Sex
|
|
Female
|
26
|
4702
|
0.6
|
41
|
4802
|
0.9
|
1.53 (0.94–2.51)
|
1.52 (0.92–2.53)
|
|
Male
|
4
|
3031
|
0.1
|
18
|
2460
|
0.7
|
2.12 (0.95–4.72)
|
2.05 (0.90–4.67)
|
|
Age, years
|
|
60–69
|
5
|
1006
|
0.5
|
13
|
936
|
1.4
|
2.44 (0.87–6.87)
|
2.50 (0.82–7.61)
|
|
70–79
|
19
|
3428
|
0.6
|
25
|
3065
|
0.8
|
1.39 (0.77–2.53)
|
1.45 (0.78–2.68)
|
|
80+
|
11
|
3040
|
0.4
|
18
|
3058
|
0.6
|
1.59 (0.75–3.37)
|
1.62 (0.76–3.46)
|
|
Comorbidity
|
|
HTN
|
|
No
|
9
|
2580
|
0.3
|
13
|
1904
|
0.7
|
1.75 (0.75–4.11)
|
1.71 (0.72–4.06)
|
|
Yes
|
26
|
5153
|
0.5
|
46
|
5358
|
0.9
|
1.66 (1.03–2.69)*
|
1.63 (0.99–2.66)
|
|
DM
|
|
No
|
17
|
5230
|
0.3
|
28
|
4357
|
0.6
|
1.88 (1.03–3.45)*
|
2.08 (1.12–3.84)*
|
|
Yes
|
18
|
2503
|
0.7
|
31
|
2905
|
1.1
|
1.43 (0.80–2.55)
|
1.42 (0.77–2.61)
|
|
Hyperlipidemia
|
|
No
|
14
|
5345
|
0.3
|
29
|
5173
|
0.6
|
2.02 (1.06–3.82)*
|
1.84 (0.95–3.54)
|
|
Yes
|
21
|
2388
|
0.9
|
30
|
2089
|
1.4
|
1.55 (0.88–2.71)
|
1.57 (0.88–2.81)
|
|
CAD
|
|
No
|
12
|
4042
|
0.3
|
23
|
3663
|
0.6
|
2.00 (0.99–4.02)
|
2.09 (1.02–4.25)*
|
|
Yes
|
23
|
3691
|
0.6
|
36
|
3599
|
1
|
1.52 (0.90–2.57)
|
1.40 (0.82–2.39)
|
|
CVA
|
|
No
|
18
|
5272
|
0.3
|
25
|
4281
|
0.6
|
1.59 (0.87–2.93)
|
1.96 (1.06–3.64)*
|
|
Yes
|
17
|
2461
|
0.7
|
34
|
2981
|
1.1
|
1.68 (0.93–3.00)
|
1.50 (0.82–2.75)
|
|
Chronic liver disease
|
|
No
|
21
|
5949
|
0.4
|
46
|
6031
|
0.8
|
2.05 (1.22–3.44)**
|
1.98 (1.17–3.35)*
|
|
Yes
|
14
|
1784
|
0.8
|
13
|
1231
|
1.1
|
1.23 (0.58–2.63)
|
1.08 (0.48–2.41)
|
- Controlling for sex, age, and every comorbidity in Table 2
- Abbreviations: PY Person-years, IR Incidence rate (per 100 person-years), HTN Hypertension, DM Diabetes mellitus, CAD Coronary artery disease, CVA Cerebrovascular accident
- *P < 0.05, **P < 0.01
