Fig. 5

Molecular mechanisms schematic diagram. The diagram shows the possible molecular mechanism on how ABT-263 inducing Bcl-2/Beclin-1 complex dependent autophagy. This study found that ABT-263 induced Beclin1-dependent autophagy by preventing Bcl-2 from binding to Beclin-1, reducing the formation of Bcl-2/Beclin-1 complex