From: The effect of comorbidities on survival in persons with Alzheimer’s disease: a matched cohort study
AD cohort | Non-AD cohort | |||
---|---|---|---|---|
Unadjusted HR (95% CI) | Adjusted HRa (95% CI) | Unadjusted HR (95% CI) | Adjusted HRa (95% CI) | |
Sociodemographic factors | ||||
Age at baseline, increase per year | 1.07 (1.07–1.07) | 1.07 (1.07–1.07) | 1.11 (1.11–1.11) | 1.12 (1.12–1.12) |
Age Category | ||||
< 80 y | 1.00 | 1.00 | 1.00 | 1.00 |
≥ 80 y | 2.03 (1.99–2.07) | 2.10 (2.06–2.14) | 3.07 (2.99–3.15) | 3.11 (3.02–3.19) |
Gender, Men (vs women) | 1.34 (1.31–1.36) | 1.58 (1.55–1.62) | 1.16 (1.13–1.19) | 1.41 (1.37–1.45) |
Socioeconomic position | ||||
Managerial/professional | 1.00 | 1.00 | 1.00 | 1.00 |
Office worker | 1.03 (0.99–1.08) | 1.09 (1.05–1.14) | 1.19 (1.13–1.26) | 1.12 (1.06–1.18) |
Farming/forestry | 1.23 (1.20–1.27) | 1.05 (1.02–1.08) | 1.73 (1.67–1.80) | 1.29 (1.24–1.34) |
Sales/industry/cleaning | 1.15 (1.12–1.18) | 1.08 (1.05–1.11) | 1.46 (1.41–1.52) | 1.24 (1.19–1.28) |
Unknown/ Did not respond | 1.37 (1.32–1.42) | 1.16 (1.22–1.21) | 1.65 (1.58–1.73) | 0.91 (0.87–0.95) |
Comorbidities (present vs absent) | ||||
Any cardiovascular disease | 1.36 (1.33–1.38) | 1.25 (1.22–1.27) | 1.68 (1.64–1.73) | 1.52 (1.49–1.56) |
Coronary artery disease | 1.45 (1.42–1.48) | 1.26 (1.24–1.29) | 1.88 (1.83–1.93) | 1.57 (1.53–1.61) |
Stroke | 1.42 (1.38–1.46) | 1.30 (1.27–1.34) | 2.12 (2.04–2.2) | 1.79 (1.73–1.86) |
Diabetes | 1.23 (1.21–1.26) | 1.25 (1.22–1.28) | 1.62 (1.56–1.67) | 1.66 (1.61–1.72) |
Asthma/COPD | 1.24 (1.21–1.28) | 1.23 (1.19–1.27) | 1.49 (1.44–1.54) | 1.50 (1.44–1.55) |
History of hip fracture | 1.57 (1.51–1.63) | 1.35 (1.30–1.41) | 2.36 (2.24–2.48) | 1.71 (1.62–1.8) |
Cancer treatment within 5 years of start of follow-up | 1.40 (1.37–1.44) | 1.29 (1.26–1.32) | 1.97 (1.92–2.02) | 1.90 (1.85–1.95) |
Any mental or behavioral disorder (exc. dementia) | 1.09 (1.07–1.11) | 1.11 (1.09–1.13) | 1.39 (1.36–1.43) | 1.41 (1.37–1.44) |