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Table 3 Mortality risk factors in the AD and non-AD cohorts

From: The effect of comorbidities on survival in persons with Alzheimer’s disease: a matched cohort study

 

AD cohort

Non-AD cohort

Unadjusted HR (95% CI)

Adjusted HRa (95% CI)

Unadjusted HR (95% CI)

Adjusted HRa (95% CI)

Sociodemographic factors

 Age at baseline, increase per year

1.07 (1.07–1.07)

1.07 (1.07–1.07)

1.11 (1.11–1.11)

1.12 (1.12–1.12)

Age Category

  < 80 y

1.00

1.00

1.00

1.00

  ≥ 80 y

2.03 (1.99–2.07)

2.10 (2.06–2.14)

3.07 (2.99–3.15)

3.11 (3.02–3.19)

 Gender, Men (vs women)

1.34 (1.31–1.36)

1.58 (1.55–1.62)

1.16 (1.13–1.19)

1.41 (1.37–1.45)

Socioeconomic position

 Managerial/professional

1.00

1.00

1.00

1.00

 Office worker

1.03 (0.99–1.08)

1.09 (1.05–1.14)

1.19 (1.13–1.26)

1.12 (1.06–1.18)

 Farming/forestry

1.23 (1.20–1.27)

1.05 (1.02–1.08)

1.73 (1.67–1.80)

1.29 (1.24–1.34)

 Sales/industry/cleaning

1.15 (1.12–1.18)

1.08 (1.05–1.11)

1.46 (1.41–1.52)

1.24 (1.19–1.28)

 Unknown/ Did not respond

1.37 (1.32–1.42)

1.16 (1.22–1.21)

1.65 (1.58–1.73)

0.91 (0.87–0.95)

Comorbidities (present vs absent)

 Any cardiovascular disease

1.36 (1.33–1.38)

1.25 (1.22–1.27)

1.68 (1.64–1.73)

1.52 (1.49–1.56)

 Coronary artery disease

1.45 (1.42–1.48)

1.26 (1.24–1.29)

1.88 (1.83–1.93)

1.57 (1.53–1.61)

 Stroke

1.42 (1.38–1.46)

1.30 (1.27–1.34)

2.12 (2.04–2.2)

1.79 (1.73–1.86)

 Diabetes

1.23 (1.21–1.26)

1.25 (1.22–1.28)

1.62 (1.56–1.67)

1.66 (1.61–1.72)

 Asthma/COPD

1.24 (1.21–1.28)

1.23 (1.19–1.27)

1.49 (1.44–1.54)

1.50 (1.44–1.55)

 History of hip fracture

1.57 (1.51–1.63)

1.35 (1.30–1.41)

2.36 (2.24–2.48)

1.71 (1.62–1.8)

 Cancer treatment within 5 years of start of follow-up

1.40 (1.37–1.44)

1.29 (1.26–1.32)

1.97 (1.92–2.02)

1.90 (1.85–1.95)

 Any mental or behavioral disorder (exc. dementia)

1.09 (1.07–1.11)

1.11 (1.09–1.13)

1.39 (1.36–1.43)

1.41 (1.37–1.44)

  1. Abbreviations: AD, Alzheimer’s disease; CI, confidence interval; COPD, Chronic obstructive pulmonary disease; exc., excluding; HR, hazard ratio; y, years
  2. a Adjusted for age sex and Socioeconomic position when appropriate