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Table 2 Predictors of the first severe infection in MPA

From: Association between body mass index and severe infection in older adults with microscopic polyangiitis: a retrospective cohort in Japan

 

Univariate model

Multivariate model

HR (95% CI)

P-value

HR (95% CI)

P-value

Age (per 10 years)

2.08

(1.16–3.67)

0.014

2.02

(1.14–3.52)

0.016

Male (vs. female)

1.11

(0.53–2.31)

0.782

1.22

(0.55–2.74)

0.624

Lung involvement

0.83

(0.38–1.84)

0.652

0.99

(0.39–5.76)

0.977

Serum creatinine (per 1.0 mg/dL)

1.10

(0.97–1.22)

0.124

1.05

(0.91–1.20)

0.504

Diabetes mellitus

1.17

(0.52–2.67)

0.703

0.77

(0.31–1.94)

0.582

mPSL pulse therapy

2.38

(1.10–5.12)

0.027

2.48

(1.07–5.76)

0.034

BMI groups

 Low BMI (<  18.5 kg/m2)

2.88

(1.35–6.16)

0.006

2.63

(1.11–6.19)

0.027

 Normal BMI (18.5–23.0 kg/m2)

Reference

 

Reference

 

 High BMI (> 23.0 kg/m2)

0.43

(0.10–1.90)

0.265

0.42

(0.09–1.93)

0.266

  1. Data are the HR, 95% CI, and P value from Cox proportional hazard regression analyses
  2. The multivariate model was adjusted for baseline characteristics, including age, sex, lung involvement, serum creatinine level, diabetes mellitus, use of mPSL pulse therapy, and BMI groups (low, normal, and high BMI). “Normal BMI” was used as the reference category
  3. Abbreviations: BMI body mass index, mPSL methylprednisolone, MPA microscopic polyangiitis, HR hazard ratio, CI confidence interval