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Table 1 Description of methods and/or instruments to evaluate IwD and/or their caregivers/significant person/proxy decision-maker

From: “Body & Brain”: effects of a multicomponent exercise intervention on physical and cognitive function of adults with dementia - study protocol for a quasi-experimental controlled trial

  Domain Measure Data from
IwD Caregiver
Screening Informed Consent X X
Anamnesis (sociodemographic and general clinical data)   X
Clinical Dementia Rating X X
Primarya Cognition   
Cognitive Function ADAS-Cog X  
Physical Fitness    
Lower Limb Function SPBB X  
Secondarya Cognition   
Cognitive Function MMSE X  
TMT
Physical Fitness    
Cardiorespiratory Capacity Modified Bruce Treadmill Test X  
Physical Fitness SFT X  
Static Balance One Leg Balance Test X  
Handgrip Strength Handgrip Dynamometer X  
Body Composition and Anthropometry   
Body Mass DXA (Hologic QDR 4500, Explorer model, version 12.4) X  
Total Fat-free Mass  
Fat Mass  
Appendicular Skeletal Mass Index  
Weight Weighting Scale X  
Height Stadiometer X  
Waist and Hip Circumferences Measuring Tape X  
Quality of Life and ADL’s Functionality   
Basic and instrumental ADL Lawton & Brody IADL Scale   X
Barthel Index  
Quality of Life QoL-AD X X
Behavioral and Psychological Symptoms of Dementia   
Neuropsychiatric Symptoms and Caregiver Distress NPI   X
Caregiver Burden    
Caregiver Well-being and Subjective Burden CarerQol-7D   X
CarerQol-Vas
Blood-based Biomarkers and Hemodynamics   
Systolic and Diastolic Blood Pressure Digital Sphygmomanometer X  
Arterial Stiffness Pulse Wave Velocity (SphygmoCor, AtCor Medical, Australia) X  
TG Concentration in blood plasma X  
TC  
LDL-C  
HDL-C  
HbA1c HPLC  
BDNF ELISA X  
VEGF  
CRP  
sICAM-1  
sVCAM-1  
MMP-9  
IL-6, IL-8, IL-10  
TNF-alfa CLIA X  
IGF-1  
Confoundersa Daily Physical Activity   
Physical Activity Levels Accelerometer-based activity monitors GT9X+ Link (ActiGraph) X  
  1. aT0 Baseline, T1 After 6-month intervention, T2 3-month follow-up