Table 4 Explorative analysis of (un)listed potentially inappropriate medication (described by ATC code and name of the substance) for older adults with chronic kidney disease. For each medication the total number of prescriptions and adverse drug events, a number needed to harm, an uncorrected p-value and a p-value corrected for the multiplicity by controlling the false discovery rate are presented. Of these medication midazolam, ofloxacin and dabigatran etexilate are included in the EU(7)-PIM list

N05CD08

Midazolam

2

1

2

< 0.001

0.118

J01XA01

Vancomycin

5

1

5

0.001

0.450

C10AC01

Cholestyramine

65

3

21.7

0.004

0.749

J02AC01

Fluconazole

219

6

36.5

0.007

0.829

N05AL05

Amisulpride

47

2

23.5

0.012

0.892

N06AG02

Moclobemide

17

1

17

0.013

0.897

R05DB05

Pentoxyverine

21

1

21

0.019

0.929

M01AG

Fenamate

24

1

24

0.024

0.943

V03AE03

Lanthanum carbonate

168

4

42

0.028

0.950

D01AC12

Fenticonazole

65

2

32.5

0.028

0.950

J01CF05

Flucloxacillin

27

1

27

0.030

0.954

J01CR04

Sultamicillin

181

4

45.3

0.036

0.961

J01EA01

Trimethoprim

747

12

62.3

0.040

0.965

L01AA01

Cyclophosphamide

32

1

32

0.041

0.966

D01AE22

Naftifine

76

2

38

0.041

0.966

D01AE15

Terbinafine

34

1

34

0.046

0.969

C09DX03

Olmesartan medoxomil, Amlodipine and Hydrochlorothiazide

36

1

36

0.051

0.972

P01AB01

Metronidazole

341

6

56.8

0.057

0.975

C05AX03

Haemorrhoid treatment

40

1

40

0.061

0.977

N02AA59

Codeine

41

1

41

0.064

0.978

J01MA01

Ofloxacin

301

5

60.2

0.083

0.983

B01AE07

Dabigatran etexilate

103

2

51.5

0.085

0.983

G01AX11

Povidone-iodine

50

1

50

0.089

0.984

R03BB01

Ipratropium bromide

110

2

55

0.098

0.985