Table 3 Risk of ADE after filling a prescription for potentially inappropriate medication (described by ATC code and name of the substance) included in the EU(7)-PIM or AT-PIM list as compared to the control group described as relative risk and risk difference with 95% confidence intervals (CI), uncorrected p-values and p-values corrected for multiplicity by controlling the false discovery rate

A02BC01

Omeprazole

EU(7)

2.95 (1.3, 6.73)

0.02 (0.01, 0.03)

0.010

0.033

A02BC02

Pantoprazole

EU(7)

3.71 (1.37, 10.05)

0.03 (0.02, 0.03)

0.010

0.033

A02BC03

Lansoprazole

EU(7)

1.87 (1.16, 3.01)

0.01 (0, 0.02)

0.010

0.033

A02BC05

Esomeprazole

EU(7)

3.87 (1.38, 10.85)

0.03 (0.02, 0.04)

0.010

0.033

A03FA01

Metoclopramide

EU(7)

2.44 (1.24, 4.79)

0.02 (0.01, 0.02)

0.010

0.033

C01AA04

Digitoxin

EU(7)

1.89 (1.17, 3.06)

0.01 (0, 0.02)

0.010

0.033

C01AA08

Metildigoxin

EU(7)

0.37 (0.17, 0.79)

−0.01 (−0.01, 0)

0.010

0.033

C02AC06

Rilmenidine

EU(7)

2.35 (1.09, 5.09)

0.01 (0, 0.03)

0.030

0.094

C03DA01

Spironolactone

EU(7)

2.47 (1.24, 4.91)

0.02 (0.01, –0.02)

0.010

0.033

N02AX02

Tramadol

EU(7), AT

2.46 (1.24, –4.89)

0.02 (0.01, 0.02)

0.010

0.033

N03AF01

Carbamazepine

EU(7)

0 (0, NaN)

−0.01 (−0.01, −0.01)

0.010

0.033

N05BA01

Diazepam

EU(7), AT

0.4 (0.2, 0.8)

−0.01 (− 0.01, 0)

0.010

0.033

N05BA04

Oxazepam

EU(7), AT

2.85 (1.11, 7.33)

0.02 (0, 0.04)

0.030

0.094

N06AA09

Amitriptyline

EU(7), AT

0.42 (0.22, 0.81)

–0.01 (−0.01, 0)

0.010

0.033

R03DA04

Theophylline

EU(7), AT

2.32 (1.22, –4.41)

0.01 (0.01, 0.02)

0.010

0.033