Fig. 5

Wortmannin increases the destructive effect of the miR-132 inhibitor on PI3K/AKT signaling pathway, cell proliferation, and inflammation divisors of chondrocytes. a Representative western blot bands of PI3K, p-Akt, and GAPDH. b Quantitative densitometry of the expression of PI3K protein. c Quantitative densitometry of the expression of the p-AKT protein. d cell proliferation of chondrocytes. e Apoptosis of chondrocytes. f Representative western blot bands of Bax, cleaved Caspase-9, cleaved Caspase-3, and GAPDH. g Quantitative densitometry of the expression of Bax protein. h Quantitative densitometry of the expression of Caspase-9 protein. i Quantitative densitometry of the expression of Caspase-3 protein. j IL-1β levels. k IL-6 levels. l IL-18 levels. Wortmannin is the PI3K inhibitor. **P < 0.01 vs inhibitor NC group; #P < 0.05, ##P < 0.01 vs miR-132 inhibitor group