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Table 4 Incidence Rate Ratio for ICHa risk factors in the CCPb population

From: Complex chronic patients as an emergent group with high risk of intracerebral haemorrhage: an observational cohort study

Age

Incidence

10,000 person-years

Incidence Rate Ratio

(exposed vs unexposed)

≥ 80 years

101 (85–120)

1.5 (0.9–2.2)

< 80 years

69 (46–100)

Cardiovascular risk factors

 Arterial hypertension

  Yes

99 (83–117)

1.6 (1.1–2.5)

  No

61 (40–89)

 Diabetes

  Yes

384 (292–497)

0.7 (0.6–1.1)

  No

99 (81–120)

 Hypercholesterolemia

  Yes

104 (83–128)

1.4 (0.9–1.8)

  No

77 (60–97)

Comorbidities

 Cardiovascular disease*

  Yes

112 (86–145)

1.4 (1.0–1.9)

  No

80 (65–97)

 Ischaemic cardiopathy

  Yes

98 (67–138)

1.2 (0.8–1.8)

  No

86 (72–103)

 Peripheral arterial disease

  Yes

111 (65–178)

1.3 (0.7–2.1)

  No

88 (74–103)

 Ischaemic stroke

  Yes

116 (67–189)

1.3 (0.8–2.2)

  No

88 (74–103)

 Heart Failure

  Yes

72 (50–100)

0.7 (0.5–1.1)

  No

96 (80–114)

 Falls (background)

  Yes

83 (51–126)

0.9 (0.6–1.4)

  No

91 (76–107)

HAS-BLED score

  ≥ 3

104 (88–122)

3.3 (1.8–6.1)

  < 3

31 (16–56)

Medication

 NOACc

  Yes

57 (12–165)

0.4 (0.1–1.4)

  No

130 (110–151)

 VKAd

  Yes

103 (77–134)

1.2 (0.9–1.7)

  No

84 (69–102)

 Antiplatelet drugs

  Yes

107 (88–130)

1.5 (1.1–2.1)

  No

69 (53–90)

Statins

  Yes

85 (68–105)

0.9 (0.6–1.2)

  No

96 (75–120)

  1. Data are presented as value (95% confidence interval). (*) Cardiovascular disease includes ischemic cardiopathy and/or peripheral arterial disease and/or ischemic stroke and/or transient ischemic accident
  2. aICH intracerebral haemorrhage, bCCP complex chronic patient, cNOAC direct oral anticoagulant, dVKA vitamin K antagonists