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Table 2 Comparison of the characteristics of CCPa population with ICHb according to sex

From: Complex chronic patients as an emergent group with high risk of intracerebral haemorrhage: an observational cohort study

 

Men

Women

p*

(N = 71)

(N = 90)

Age (years)

83.6 [9.1]

88.9 [7.7]

< 0.001

  < 80 years

72.1 [6.9]

72.6 [7.0]

0.861

  ≥ 80 years

87.8 [5.5]

90.7 [5.3]

0.003

Cardiovascular risk factors

 Arterial hypertension

60 (84.5)

74 (82.2)

0.700

 Diabetes

30 (42.3)

28 (31.1)

0.144

 Hypercholesterolemia

31 (43.7)

58 (64.4)

0.008

Comorbidities

 Cardiovascular disease

35 (49.3)

24 (26.7)

0.003

 Ischemic cardiopathy

22 (31.0)

11 (12.2)

0.003

 Ischemic stroke/Transient ischemic accident

8 (11.3)

8 (8.9)

0.616

 Peripheral artery disease

8 (11.3)

9 (10.0)

0.795

 Atrial fibrillation

17 (23.9)

34 (37.8)

0.061

 Heart failure

13 (18.3)

21 (23.3)

0.438

 Thromboembolism

4 (5.6)

9 (10.0)

0.313

 Chronic kidney disease

24 (33.8)

12 (13.3)

0.002

 Chronic liver disease

1 (1.4)

0 (0.0)

0.259

Other conditioning factors

 Institutionalized

2 (2.8)

7 (7.8)

0.174

 Record of previous falls

5 (7.0)

16 (17.8)

0.045

 Cognitive impairment or dementia

13 (18.3)

25 (27.8)

0.160

 Alcohol consumption

14 (19.7)

5 (5.6)

0.006

 Bleeding predisposition

10 (14.1)

3 (3.3)

0.013

Clinical data

 Systolic blood pressure (mmHg)

134.7 [12.2]

131.3 [14.3]

0.096

 Glycosylated haemoglobin A1c (%)

6.6 [1.5]

6.1 [1.3]

0.039

 Glomerular filtration rate (mL/min/1.73m2)

66.9 [25.3]

65.9 [16.7]

1.000

 CHA2DS2-VASC score

3 [0.00]

5.5 [0.7]

0.102

 HAS-BLED score

3.7 [1.0]

3.3 [0.7]

0.014

 Barthel index

70.3 [23.7]

75.6 [24.7]

0.145

Medication

 Oral anticoagulant (VKAc o NOACd)

22 (31.0)

32 (35.6)

0.542

 NOACd

2.0 (2.8)

1.0 (1.1)

0.427

 NSAIDe

49 (69.0)

63 (70.0)

0.893

 Antiplatelet drugs

54 (76.1)

49 (54.4)

0.005

 Statin

37 (52.1)

48 (53.3)

0.878

 SSRIf

17 (23.9)

42 (46.7)

0.003

 PPIg

62 (87.3)

74 (82.2)

0.375

  1. Data are presented as number of patients (%) or mean [standard deviation] depending on the type of variable, whether qualitative or continuous, respectively. (*) The p-value corresponds to the contrast of differences in proportions for qualitative variables and the non-parametric test of the Mann-Whitney U. (**) CHA2DS2-VASC score only in patients with atrial fibrillation
  2. aCCP complex chronic patient, bICH intracerebral haemorrhage, cVKA vitamin K antagonists, dNOAC new oral anticoagulant, eNSAID non-steroidal anti-inflammatory drug, fSSRI selective serotonin reuptake inhibitors, gPPI Proton pump inhibitor