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Table 1 Characteristics of the population, overall and acGEIcording to the number of medications taken daily

From: Medication burden and inappropriate prescription risk among elderly with advanced chronic kidney disease

 Overall populationTertile groups of number of drug prescriptions daily
Tertile 1Tertile 2Tertile 3
Number of patients556 patients155 (28%)210 (38%)191 (34%)
Number of daily drug prescriptions: n [IQR], (range) 6.0 [5.0; 7.0], (2–7)9.0 [8.0; 10.0], (8–10)12.0 [11.0; 13.0], (11–24)
Patients’ characteristics
 Age (year): Mean ± SD82.5 ± 4.882.6 ± 5.082.6 ± 4.682.2 ± 4.9
 Male318 (57%)94 (61%)115 (55%)109 (57%)
Blood pressure (mmHg)
 SBP Median [IQ]142.0 [130.0;160.0]140.0 [130.0; 160.0]142.0 [130.0; 159.0]143.5 [130.0; 160.0]
 DBP Median [IQ]73.5 [69.0; 80.0]73.0 [69.0; 80.0]75.0 [70.0; 80.0]72.0 [68.0; 80.0]
Body mass index (BMI): (kg/m2)26.5 ± 5.025.7 ± 4.826.3 ± 4.927.3 ± 5.1a
Diabetes219 (39%)53 (34%)68 (32%)98 (51%)b
Chronic heart failure194 (35%)52 (34%)65 (31%)77 (40%)
Chronic respiratory disease62 (11%)16 (10%)17 (8%)29 (15%)
Peripheral vascular disease138 (25%)39 (25%)48 (23%)51 (27%)
Cerebrovascular disease75 (13%)22 (14%)25 (12%)28 (15%)
Dysrhythmia155 (28%)35 (23%)61 (29%)59 (31%)
Active malignancy55 (10%)16 (10%)20 (10%)19 (10%)
Behavioral disorders53 (10%)19 (12%)19 (9%)15 (8%)
Residence: independently at home508 (91%)141 (91%)195 (93%)172 (90%)
Mobility: walks unassisted499 (90%)136 (88%)190 (90%)173 (91%)
Hemoglobin (g/dl) median [IQ]11.4 [10.4; 12.4]11.3 [10.2; 12.4]11.5 [10.5; 12.3]11.3 [10.4; 12.4]
eGFR (CG) (ml/min) Median [IQ]13.0 [10.1; 15.4]25.0 [16.8; 30.9]23.9 [19.0; 30.4]25.2 [18.4; 30.1]
eGFR (MDRD) (ml/min/1.73 m2) Median [IQ]14.2 [11.1; 16.7]14.3 [10.9; 16.7]14.4 [11.3; 17.1]13.8 [10.9; 16.5]
Proteinuria (g/g): n(%)
 < 0.5174 (31%)45 (29%)78 (37%)51 (27%)
 [0.5–1105 (19%)40 (26%)40 (19%)25 (13%)
 ≥ 1212 (38%)57 (37%)70 (33%)85 (45%)
 Miss65 (12%)13 (8%)22 (10%)30 (16%)a
Nephropathy
 Vascular204 (37%)49 (32%)93 (44%)62 (32%)a
 Diabetic135 (24%)31 (20%)37 (18%)67 (35%)
 Undetermined99 (18%)32 (21%)37 (18%)30 (16%)
 Glomerulopathy57 (10%)17 (11%)25 (12%)15 (8%)
 Tubulointerstitial61 (11%)26 (17%)18 (9%)17 (9%)
  1. a: Tertile1 vs Tertile3, p-value < 0.05 in univariate analysis
  2. b: Tertile1 vs Tertile3, p-value < 0.05 in multivariate analysis
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