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Table 5 MoCA scores for patients with/without use of antidepressant medication, depression diagnosis from medical history, and by use of strong anticholinergic burden concomitant medication

From: Effect of mirabegron on cognitive function in elderly patients with overactive bladder: MoCA results from a phase 4 randomized, placebo-controlled study (PILLAR)

 Placebo (n = 411)Mirabegron Total (n = 425)
Total score at BL, mean (SD)Total score at EoT, mean (SD)Change in Total score, meanTotal score at BL, mean (SD)Total score at EoT, mean (SD)Change in Total score, mean
Use of antidepressant medicationa
 No (n = 695)26.9 (2.9)27.1 (2.8)0.226.9 (2.7)27.0 (2.7)0.0
 Yes (n = 141)26.6 (2.6)26.9 (2.4)0.326.5 (3.0)26.6 (2.8)0.2
Depression diagnosis from medical historyb
 No (n = 683)26.8 (2.9)27.0 (2.7)0.227.0 (2.5)27.0 (2.7)0.0
 Yes (n = 153)26.9 (2.6)27.1 (2.6)0.126.2 (3.3)26.7 (2.8)0.4
Use of anticholinergic burden concomitant medicationc
 No (n = 767)26.8 (2.8)27.1 (2.7)0.226.8 (2.7)26.9 (2.7)0.0
 Yes (n = 69)26.6 (3.5)26.6 (3.1)027.0 (2.9)27.4 (2.4)0.4
  1. aN = 345 for placebo and 350 for mirabegron total for No, N = 66 for placebo and 75 for mirabegron total for Yes
  2. bN = 341 for placebo and 342 for mirabegron total for No, N = 70 for placebo and 83 for mirabegron total for Yes
  3. cN = 380 for placebo and 387 for mirabegron total for No, N = 31 for placebo and 38 for mirabegron total for Yes
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