Table 5 MoCA scores for patients with/without use of antidepressant medication, depression diagnosis from medical history, and by use of strong anticholinergic burden concomitant medication
|  | Placebo (n = 411) | Mirabegron Total (n = 425) | ||||
|---|---|---|---|---|---|---|
Total score at BL, mean (SD) | Total score at EoT, mean (SD) | Change in Total score, mean | Total score at BL, mean (SD) | Total score at EoT, mean (SD) | Change in Total score, mean | |
Use of antidepressant medicationa | ||||||
 No (n = 695) | 26.9 (2.9) | 27.1 (2.8) | 0.2 | 26.9 (2.7) | 27.0 (2.7) | 0.0 |
 Yes (n = 141) | 26.6 (2.6) | 26.9 (2.4) | 0.3 | 26.5 (3.0) | 26.6 (2.8) | 0.2 |
Depression diagnosis from medical historyb | ||||||
 No (n = 683) | 26.8 (2.9) | 27.0 (2.7) | 0.2 | 27.0 (2.5) | 27.0 (2.7) | 0.0 |
 Yes (n = 153) | 26.9 (2.6) | 27.1 (2.6) | 0.1 | 26.2 (3.3) | 26.7 (2.8) | 0.4 |
Use of anticholinergic burden concomitant medicationc | ||||||
 No (n = 767) | 26.8 (2.8) | 27.1 (2.7) | 0.2 | 26.8 (2.7) | 26.9 (2.7) | 0.0 |
 Yes (n = 69) | 26.6 (3.5) | 26.6 (3.1) | 0 | 27.0 (2.9) | 27.4 (2.4) | 0.4 |