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Table 2 Concomitant non-OAB medications relevant to cognition during double-blind treatment period

From: Effect of mirabegron on cognitive function in elderly patients with overactive bladder: MoCA results from a phase 4 randomized, placebo-controlled study (PILLAR)

n (%)Placebo (n = 442)Mirabegron Total (n = 445)
CONCOMITANT ANTIDEPRESSANTS
 SSRIs54 (12.2)53 (11.9)
  Citalopram14 (3.2)9 (2.0)
  Sertraline11 (2.5)4 (0.9)
  Escitalopram oxalate5 (1.1)8 (1.8)
  Escitalopram5 (1.1)7 (1.6)
  Fluoxetine8 (1.8)4 (0.9)
  Citalopram hydrobromide3 (0.7)6 (1.3)
  Paroxetine1 (0.2)6 (1.3)
  Sertraline hydrochloride4 (0.9)3 (0.7)
  Fluoxetine hydrochloride3 (0.7)3 (0.7)
  Paroxetine hydrochloride03 (0.7)
 Other antidepressants23 (5.2)31 (7.0)
  Trazodone13 (2.9)17 (3.8)
  Duloxetine3 (0.7)4 (0.9)
  Duloxetine hydrochloride4 (0.9)2 (0.4)
  Mirtazapine2 (0.5)3 (0.7)
  Trazodone hydrochloride03 (0.7)
  Venlafaxine hydrochloride2 (0.5)1 (0.2)
  Desvenlafaxine succinate01 (0.2)
  Nefazodone01 (0.2)
  Oxitriptan01 (0.2)
  Venlafaxine1 (0.2)0
  Vortioxetine1 (0.2)0
 Non-selective monoamine reuptake inhibitors7 (1.6)9 (2.0)
  Amitriptyline2 (0.5)7 (1.6)
  Doxepin1 (0.2)1 (0.2)
  Nortriptyline2 (0.5)0
  Amitriptyline hydrochloride01 (0.2)
  Imipramine1 (0.2)0
  Nortriptyline hydrochloride1 (0.2)0
 Diazepines, oxazepines, thiazepines and oxepines3 (0.7)1 (0.2)
  Quetiapine fumarate3 (0.7)1 (0.2)
 Other antipsychotics02 (0.4)
  Aripiprazole01 (0.2)
  Risperidone01 (0.2)
CONCOMITANT ANTICHOLINERGICS
 Antihistamines for systemic use38 (8.6)41 (9.2)
  Hydroxyzine2 (0.5)2 (0.4)
  Hydroxyzine hydrochloride1 (0.2)1 (0.2)
 Aminoalkyl ethers15 (3.4)16 (3.6)
  Diphenhydramine hydrochloride10 (2.3)11 (2.5)
  Diphenhydramine4 (0.9)4 (0.9)
  Dimenhydrinate1 (0.2)1 (0.2)
  Carbinoxamine maleate01 (0.2)
 Piperazine derivatives3 (0.7)2 (0.4)
  Meclozine2 (0.5)1 (0.2)
 Phenothiazine derivatives1 (0.2)1 (0.2)
  Promethazine1 (0.2)0
  Promethazine hydrochloride01 (0.2)
 Substituted alkylamines02 (0.4)
  Chlorphenamine maleate02 (0.4)
 Cough and cold preparations17 (3.8)20 (4.5)
  Promethazine with codeine01 (0.2)
 Carbamic acid esters5 (1.1)1 (0.2)
  Carisoprodol2 (0.5)1 (0.2)
 Synthetic anticholinergics, esters with tertiary amine groups02 (0.4)
  Dicycloverine hydrochloride02 (0.4)
  1. OAB overactive bladder, SSRIs selective serotonin reuptake inhibitors
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