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Table 8 Illustrative sample size calculations for continuous measures

From: Developing a composite outcome measure for frailty prevention trials – rationale, derivation and sample size comparison with other candidate measures

Measure

MCID

SD

Unadjusted (per group)

Adjusted (per group)

Fried frailty score

0.3a

1.2

352

264

4 m walk speed

0.05

0.25

526

395

4 m walk speed

0.10

0.25

132

99

SPPB

0.5

2.5

526

395

SPPB

1.0

2.5

132

99

  1. All two-sided, alpha 0.05, power 0.90, with correlation of 0.5 between baseline and follow up measures
  2. aMCID unknown, but value of 0.3 derived from change seen in trial by Serra-Prat et al. [10]
  3. SPPB Short Physical Performance Battery