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Table 8 Illustrative sample size calculations for continuous measures

From: Developing a composite outcome measure for frailty prevention trials – rationale, derivation and sample size comparison with other candidate measures

MeasureMCIDSDUnadjusted (per group)Adjusted (per group)
Fried frailty score0.3a1.2352264
4 m walk speed0.050.25526395
4 m walk speed0.100.2513299
  1. All two-sided, alpha 0.05, power 0.90, with correlation of 0.5 between baseline and follow up measures
  2. aMCID unknown, but value of 0.3 derived from change seen in trial by Serra-Prat et al. [10]
  3. SPPB Short Physical Performance Battery