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Table 7 Illustrative sample size calculations; transition from baseline prefrail status; 2 year follow up

From: Developing a composite outcome measure for frailty prevention trials – rationale, derivation and sample size comparison with other candidate measures

To detect relative risk reduction of:

Transition to frail (per group)

Transition to frail/dead/too ill (per group)

Ordinal (robust vs prefrail vs non frail/dead/too ill (per group)

20%

3621

815

177

25%

2389

558

117

30%

1576

360

87

40%

853

197

55

50%

520

123

38

  1. All two-sided, alpha 0.05, power 0.90