Developing a composite outcome measure for frailty prevention trials – rationale, derivation and sample size comparison with other candidate measures

Table 6 Interpolated frailty state transition probabilities at one and two years from baseline prefrail state

Baseline state	Follow up state	1 year (interpolated)	2 year (interpolated)	4 year (measured)
Assumes all dropouts are due to illness	Robust	0.108	0.159	0.176
	Prefrail	0.688	0.494	0.286
	Frail	0.087	0.113	0.099
	Dead/too ill	0.117	0.234	0.439
Assumes no dropouts are due to illness	Robust	0.109	0.159	0.176
	Prefrail	0.688	0.494	0.286
	Frail	0.087	0.113	0.099
	Dead	0.019	0.044	0.093
	Lost to follow up	0.097	0.190	0.346
Assumes 50% of dropouts are due to illness	Robust	0.109	0.159	0.176
	Prefrail	0.688	0.494	0.286
	Frail	0.088	0.113	0.099
	Dead/too ill	0.068	0.139	0.266
	Lost to follow up	0.049	0.095	0.173

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