Certainty assessment | Summary of findings | |||||||||
---|---|---|---|---|---|---|---|---|---|---|
№ of participants (studies) Follow-up | Risk of bias | Inconsistency | Indirectness | Imprecision | Publication bias | Overall certainty of evidence | Study event rates (%) | Anticipated absolute effects | ||
With NIE | With IE | Risk with NIE | Risk difference with IE | |||||||
LEIPAD – Overall | ||||||||||
1765 (2 observational studies) | very serious a | very serious b,c | not serious | not serious | very strong association all plausible residual confounding would suggest spurious effect, while no effect was observed | ⨁◯◯◯ VERY LOW | 1009 | 756 | – | SMD 0.11 higher (0.1 lower to 0.32 higher) |
LEIPAD - Physical functions | ||||||||||
280 (2 observational studies) | very serious a | not serious | not serious | serious d | very strong association all plausible residual confounding would suggest spurious effect, while no effect was observed | ⨁⨁◯◯ LOW | 161 | 119 | – | SMD 0.14 higher (0.1 lower to 0.38 higher) |
LEIPAD - Self-care skills | ||||||||||
280 (2 observational studies) | very serious a | very serious b,c | not serious | very serious d, e | very strong association all plausible residual confounding would suggest spurious effect, while no effect was observed | ⨁◯◯◯ VERY LOW | 161 | 119 | – | SMD 0.15 higher (0.47 lower to 0.77 higher) |
LEIPAD - Cognitive functions | ||||||||||
280 (2 observational studies) | very serious a | not serious | not serious | serious d | strong association all plausible residual confounding would suggest spurious effect, while no effect was observed | ⨁◯◯◯ VERY LOW | 161 | 119 | – | SMD 0.26 lower (0.5 lower to 0.02 lower) |
LEIPAD - Depression and anxiety | ||||||||||
280 (2 observational studies) | very serious a | not serious | not serious | serious d | strong association all plausible residual confounding would suggest spurious effect, while no effect was observed | ⨁◯◯◯ VERY LOW | 161 | 119 | – | SMD 0.24 lower (0.48 lower to 0) |
LEIPAD - Social functions | ||||||||||
280 (2 observational studies) | very serious a | not serious | not serious | serious d | strong association all plausible residual confounding would suggest spurious effect, while no effect was observed | ⨁◯◯◯VERY LOW | 161 | 119 | – | SMD 0.35 SD higher (0.11 higher to 0.59 higher) |
LEIPAD - Sexual functions | ||||||||||
280 (2 observational studies) | very serious a | not serious | not serious | serious d | all plausible residual confounding would suggest spurious effect, while no effect was observed | ⨁◯◯◯ VERY LOW | 161 | 119 | – | SMD 0.78 higher (0.5 higher to 1.06 higher) |
LEIPAD - Life Satisfaction | ||||||||||
85 (2 observational studies) | very serious a | not serious | not serious | serious d | very strong association all plausible residual confounding would suggest spurious effect, while no effect was observed | ⨁⨁◯◯ LOW | 43 | 42 | – | SMD 0.06 higher (0.37 lower to 0.48 higher) |