Table 4 Multivariate linear regression analysis of factors related to absolute changes in serum creatinine and eGFR, comparing the level 3 months after DLI reversal (T1) and preoperative baseline (T0)
Serum Creatinine | eGFR | |||||||
|---|---|---|---|---|---|---|---|---|
Multivariate regression coefficient | Beta | 95% CI | p value | Multivariate regression coefficient | Beta | 95% CI | p value | |
Patient-related factors | ||||||||
Age | 0.009 | 0.313 | 0.002 – 0.015 | 0.009 | -0.617 | -0.304 | -1.134 - -0.100 | 0.020 |
Sex (male) | -0.034 | -0.054 | -0.191 – 0.122 | 0.664 | 0.778 | 0.017 | -8.021 – 9.576 | 0.860 |
Diabetes mellitus | 0.038 | 0.048 | -0.156 – 0.232 | 0.697 | -4.358 | -0.077 | -15.960 – 7.244 | 0.454 |
Hypertension | -0.010 | -0.016 | -0.166 – 0.145 | 0.895 | -1.962 | -0.042 | -11.244 – 7.320 | 0.673 |
COPD | -0.030 | -0.021 | -0.368 – 0.307 | 0.858 | 6.940 | 0.066 | -13.170 – 27.050 | 0.491 |
ASA Score | 0.057 | 0.147 | -0.368 – 0.307 | 0.236 | -3.300 | -0.118 | -9.018 – 2.417 | 0.252 |
Neoadjuvant Chemotherapy | 0.097 | 0.139 | -0.074 – 0.268 | 0.260 | -6.607 | -0.132 | -16.741 – 3.528 | 0.196 |
Adjuvant Chemotherapy | -0.026 | -0.042 | -0.175 – 0.123 | 0.726 | -1.592 | -0.036 | -10.720 - 7536 | 0.728 |
Serum creatinine at T0 | 0.754 | 0.494 | 0.320 – 1.187 | 0.001 | ||||
eGFR at T0 | 0.775 | 0.582 | 0.421 – 1.130 | <0.001 | ||||
Procedure-related factors | ||||||||
CDC (LAR) | -0.088 | -0.115 | -0.280 – 0.103 | 0.358 | 4.475 | 0.081 | -7.021 – 15.971 | 0.438 |
Blood transfusion (LAR) | -0.040 | -0.061 | -0.208 – 0.128 | 0.633 | 0.892 | 0.019 | -9.257 – 11.041 | 0.861 |
Operation time (LAR) | 0 | -0.063 | -0.001 – 0.001 | 0.590 | 0.017 | 0.058 | -0.040 – 0.073 | 0.554 |
CDC (DLI) | -0.031 | -0.100 | -0.103 – 0.041 | 0.391 | 1.022 | 0.046 | -3.301 – 5.345 | 0.637 |
Time to DLI reversal | 0 | 0.139 | 0.000 – 0.001 | 0.227 | -0.022 | -0.090 | -0.068 – 0.025 | 0.351 |