Table 5 Model 2: Results of linear mixed model for effect of dementia (CDR-SoB) measured longitudinally on P-ADL level over time
Covariates | Unadjusted models | Adjusted models | ||
|---|---|---|---|---|
Regr. coeff. (SE) | p-value1 | Regr. coeff. (SE) | p-value1 | |
Effect of main variable | ||||
 Time | 0.25 (0.12) | 0.038 | 0.27 (0.12) | 0.021 |
 Time*Time | 0.005 (0.009) | 0.580 | − 0.0004 (0.009) | 0.964 |
 Time*Time*Time | −0.0002 (0.0002) | 0.267 | −0.00007 (0.0002) | 0.687 |
 CDR-SoB | 0.61 (0.05) | < 0.001 | 0.55 (0.05) | < 0.001 |
 Time*CDR-SoB | −0.01 (0.01) | 0.242 | −0.01 (0.01) | 0.193 |
 Time*Time*CDR-SoB | 0.0001 (0.0008) | 0.887 | 0.0003 (0.0008) | 0.672 |
 Time*Time*Time* CDR-SoB | 0.000006 (0.00002) | 0.704 | −0.00000001 (0.00002) | 0.996 |
Effect of additional variables at baseline | ||||
 Socio–demographic information | ||||
  Age (per years) | 0.003 (0.02) | 0.886 | 0.01 (0.02) | 0.530 |
  Women | −0.49 (0.33) | 0.143 | −0.23 (0.32) | 0.476 |
  Single | −0.65 (0.30) | 0.028 | −0.46 (0.29) | 0.116 |
Effect of additional variables measured longitudinally | ||||
 GMHR | ||||
  Poor / Fair (Good/Excellent– ref.) | 2.04 (0.16) | < 0.001 | 1.77 (0.16) | < 0.001 |
 NPI-NH | ||||
  Agitation sub-syndrome | 0.07 (0.01) | < 0.001 | 0.04 (0.01) | 0.002 |
  Psychosis sub-syndrome | 0.07 (0.02) | 0.001 | −0.002 (0.02) | 0.915 |
  Affective sub-syndrome | 0.11 (0.02) | < 0.001 | 0.06 (0.02) | 0.001 |
  Apathy | 0.22 (0.03) | < 0.001 | 0.14 (0.03) | < 0.001 |
 Use of psychotropic medication | ||||
  Antipsychotics | 0.19 (0.26) | 0.450 | 0.08 (0.24) | 0.730 |
  Antidepressants | −0.003 (0.21) | 0.988 | − 0.17 (0.20) | 0.391 |
  Anxiolytics | 0.06 (0.22) | 0.780 | 0.03 (0.21) | 0.894 |
  Hypnotics/Sedatives | 0.42 (0.21) | 0.041 | 0.17 (0.20) | 0.382 |
  Anti-dementia medication | −1.44 (0.22) | < 0.001 | −1.17 (0.21) | < 0.001 |
 NH Characteristics | ||||
  RU (vs SCU) | 0.71 (0.24) | 0.003 | 0.59 (0.23) | 0.009 |