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Table 1 Demographic baseline characteristics of the study group according to renal function

From: Renal dysfunction is associated with decline of cognitive function in community-dwelling older adults: Korean frailty and aging cohort study

 

Overall

(N = 2847)

Quartile 1

(n = 711)

Quartile 2

(n = 712)

Quartile 3

(n = 712)

Quartile 4

(n = 712)

P

eGFR, mL/min/1.73 m2

77.5 ± 14.3

91.7 ± 3.2

84.9 ± 1.8a,c

76.1 ± 3.7a,b

57.2 ± 10.8a,b,c

< 0.001

Demographic characteristics

 Age, years

76.0 ± 3.9

73.7 ± 3.1

76.2 ± 3.6a,c

76.7 ± 4.0a,b

77.4 ± 3.8a,b,c

< 0.001

 Men, n (%)

1333 (46.8)

262 (36.8)

318 (44.7)a

361 (50.7)a

392 (55.1)a,b

< 0.001

 Education, years

8.4 ± 5.1

8.0 ± 4.8

8.2 ± 5.0

8.8 ± 5.1a

8.7 ± 5.4a

0.005

 Smoking, n (%)

182 (6.4)

34 (4.8)

52 (7.3)

44 (6.2)

52 (7.3)

0.164

 Alcohol consumption, n (%)

1416 (49.7)

360 (50.6)

363 (51.0)

364 (51.1)

367 (51.5)

0.717

Medical history

 Hypertension, n (%)

1637 (57.5)

335 (47.2)

379 (53.2)

430 (60.4)a,b

493 (69.2)a,b,c

< 0.001

 Diabetes mellitus, n (%)

614 (21.6)

135 (19.0)

135 (19.0)

138 (19.4)

206 (29.0)a,b,c

< 0.001

 Dyslipidemia, n (%)

898 (31.9)

225 (32.1)

218 (30.8)

217 (31.0)

238 (33.7)

0.629

 Coronary artery disease, n (%)

222 (8.0)

35 (5.0)

54 (7.7)

54 (7.7)

79 (11.2)a

< 0.001

Clinical results

 BMI, kg/m2

24.4 ± 3.1

24.1 ± 3.0

24.3 ± 2.9

24.3 ± 3.0

24.8 ± 3.2a,b

0.001

 ASM index, kg/m2

6.6 ± 1.1

6.4 ± 1.1

6.6 ± 1.1

6.6 ± 1.2a

6.7 ± 1.2a,b

< 0.001

 SBP, mmHg

131.1 ± 15.7

130.5 ± 15.4

131.2 ± 15.3

131.4 ± 15.9

131.3 ± 16.1

0.703

 DBP, mmHg

77.4 ± 9.3

78.0 ± 9.1

77.4 ± 9.1

77.5 ± 9.4

76.8 ± 9.8

0.137

 GDS score

3.2 ± 3.7

3.1 ± 3.6

3.3 ± 3.7

2.9 ± 3.5

3.5 ± 3.8

0.061

Laboratory results

 Albumin, g/dL

4.2 ± 0.4

4.16 ± 0.4

4.17 ± 0.4

4.24 ± 0.4

4.20 ± 0.4

0.001

 Creatinine, mg/dL

0.8 ± 0.3

0.6 ± 0.1

0.7 ± 0.1a,c

0.9 ± 0.1a,b

1.2 ± 0.4a,b,c

< 0.001

 Triglyceride, mg/dL

121.8 ± 60.9

114.7 ± 54.1

115.5 ± 55.5

123.3 ± 65.8

133.5 ± 65.7a,b,c

< 0.001

 HDL-C, mg/dL

52.4 ± 13.9

54.4 ± 14.0

53.4 ± 13.6

52.3 ± 13.8a

49.5 ± 13.9a,b,c

< 0.001

 LDL-C, mg/dL

108.5 ± 33.3

111.2 ± 31.3

109.1 ± 33.9

108.8 ± 33.7

104.9 ± 33.9a

0.004

 Sodium, mmol/L

141.3 ± 2.4

141.1 ± 2.2

141.4 ± 2.3

141.5 ± 2.7

141.0 ± 2.4b,c

0.003

 HbA1c, %

6.10 ± 0.83

6.02 ± 0.792

6.02 ± 0.762

6.01 ± 0.834

6.19 ± 0.909a,b,c

< 0.001

 Hemoglobin, g/dL

13.4 ± 1.4

13.4 ± 1.3

13.5 ± 1.4

13.6 ± 1.4

13.2 ± 1.6b,c

< 0.001

 hsCRP, mg/dL

1.5 ± 2.6

1.3 ± 2.2

1.5 ± 2.8

1.5 ± 2.5

1.8 ± 2.9a,b,c

< 0.001

 Proteinuria, n (%)

84 (3.0)

7 (8.3)

8 (9.5)

17 (20.2)

52 (61.9)a,b,c

< 0.001

  1. ASM appendicular skeletal muscle mass, BMI body mass index, DBP diastolic blood pressure, eGFR estimated glomerular filtration rate, GDS Geriatric Depression Scale-Korean version, HbA1c glycated hemoglobin, HDL-C high-density lipoprotein, hsCRP high-sensitivity C-reactive protein, LDL-C low-density lipoprotein, SBP systolic blood pressure
  2. ap < 0.05 vs. quartile 1
  3. bp < 0.05 vs. quartile 2
  4. cp < 0.05 vs. quartile 3
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BMC Geriatrics

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