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Table 2 Risk factors for the development of early post-transplant infection in younger recipients

From: Epidemiology, risk factors, and clinical impact of early post-transplant infection in older kidney transplant recipients: the Korean organ transplantation registry study

<  60 year-old

Univariate

Multivariate

HR (95% CI)

p

HR (95% CI)

p

Sex, female

1.276 (1.074–1.515)

0.006

1.323 (1.103–1.587)

0.003

BMI (kg/m2)

1.017 (0.993–1.041)

0.173

  

Cause of ESRD

 Diabetes mellitus

1

   

 Hypertension

1.007 (0.756–1.341)

0.964

  

 Glomerulonephritis

1.007 (0.796–1.275)

0.952

  

 ADPKD

1.100 (0.712–1.700)

0.666

  

 Others

1.209 (0.761–1.921)

0.421

  

 Unknown

0.913 (0.691–1.205)

0.518

  

Duration of dialysis (month)

1.002 (1.001–1.003)

<  0.001

1.000 (0.999–1.002)

0.377

Diabetes mellitus

1.015 (0.834–1.237)

0.879

  

Hypertension

1.021 (0.779–1.336)

0.882

  

Cardiovascular disease

1.520 (1.167–1.980)

0.002

1.454 (1.108–1.906)

0.007

Creatinine, baseline (mg/dL)

1.004 (0.979–1.030)

0.761

  

Creatinine, discharge (mg/dL)

1.015 (0.916–1.125)

0.772

  

Re-transplantation

1.065 (0.782–1.450)

0.690

  

Deceased donor

1.553 (1.306–1.846)

<  0.001

1.409 (1.120–1.772)

0.003

Donor age (year)

1.010 (1.003–1.017)

0.004

1.008 (1.001–1.015)

0.022

Donor sex, female

1.346 (1.129–1.604)

0.001

1.192 (0.992–1.433)

0.061

Desensitization

1.015 (0.829–1.243)

0.883

  

ABO incompatibility

0.757 (0.586–0.979)

0.034

0.934 (0.708–1.230)

0.626

Presence of DSA

1.536 (1.128–2.092)

0.006

1.427 (1.016–2.006)

0.040

Length of hospitalization after KT (day)

1.015 (1.011–1.020)

<  0.001

1.011 (1.006–1.017)

<  0.001

Induction immunosuppression

No use

1

 

1

 

 Basiliximab

2.226 (0.831–5.959)

0.111

2.511 (0.479–8.252)

0.051

 ATG

2.760 (1.016–7.493)

0.046

2.589 (0.952–7.042)

0.062

 Basiliximab + ATG

2.894 (0.953–8.793)

0.061

2.337 (0.767–7.118)

0.135

Calcineurin inhibitors

 No use

1

   

 Tacrolimus

1.345 (0.503–3.597)

0.555

  

 Cyclosporine

1.146 (0.377–3.481)

0.810

  

Steroid

1.477 (0.735–2.970)

0.273

  

Acute rejection

2.993 (2.499–3.585)

<  0.001

2.637 (2.455–3.426)

<  0.001

  1. BMI body mass index, ESRD end stage renal disease, ADPKD autosomal dominant polycystic kidney disease, DSA donor specific antibody, KT kidney transplantation, ATG anti-thymocyte globulin