From: Clinical characteristics and manifestations in older patients with COVID-19
Younger old (n = 216) | Oldest-old (n = 91) | P | |
---|---|---|---|
Age (years) | 66.0 (63.0–69.0) | 79.0 (76.0–82.0) | < 0.001 |
Male | 96 (44.4%) | 57 (62.6%) | 0.004 |
Comorbidity | |||
Any | 143 (66.2%) | 79 (86.8%) | < 0.001 |
Hypertension | 96 (44.4%) | 62 (68.1%) | < 0.001 |
Diabetes | 37 (17.1%) | 15 (16.5%) | 0.890 |
CAD | 27 (12.5%) | 23 (25.3%) | 0.006 |
Cerebral infarction | 8 (3.7%) | 13 (14.3%) | 0.001 |
Cancer | 6 (2.8%) | 3 (3.3%) | 1.000 |
CKD | 3 (1.4%) | 4 (4.4%) | 0.233 |
COPD | 3 (1.4%) | 4 (4.4%) | 0.233 |
Laboratory findings | |||
White blood cells (109/L) | 5.72 (4.34–7.39) | 5.96 (4.74–8.12) | 0.155 |
Neutrophils (109/L) | 3.70 (2.54–5.47) | 4.30 (3.37–6.54) | 0.006 |
Lymphocytes (109/L) | 1.18 (0.73–1.68) | 0.85 (0.59–1.29) | < 0.001 |
< 0.8 | 58 (26.9%) | 43 (47.3%) | 0.001 |
Hemoglobin (g/L) | 121.0 (112.0–131.0) | 121.0 (109.0–133.0) | 0.660 |
Platelet (109/L) | 213.0 (165.3–269.5) | 197.0 (134.0–242.0) | 0.011 |
< 100 | 10 (4.6%) | 9 (9.9%) | 0.081 |
CRP (mg/L) | 18.90 (1.37–73.09) | 53.55 (12.28–73.03) | 0.001 |
ALT (U/L) | 24.0 (16.0–35.8) | 23.0 (16.0–39.0) | 0.829 |
AST (U/L) | 25.0 (18.0–35.8) | 30.0 (21.0–48.0) | 0.002 |
Albumin (g/L) | 37.1 (33.6–40.0) | 35.0 (32.0–37.7) | < 0.001 |
< 30 | 11 (5.1%) | 7 (7.7%) | 0.376 |
Urea nitrogen (mmol/L) | 5.10 (4.00–6.51) | 7.70 (4.80–11.31) | < 0.001 |
Creatinine (μmol/L) | 60.0 (50.0–70.0) | 68.0 (57.0–100.0) | < 0.001 |
Blood glucose (mmol/L) | 5.80 (5.06–7.74) | 5.79 (4.90–7.01) | 0.658 |
Creatine kinase (U/L) | 59.0 (42.0–86.5) | 62.0 (42.5–150.0) | 0.103 |
LDH (U/L) | 252.0 (200.0–346.0) | 289.0 (230.0–452.0) | 0.001 |
CK-MB (ng/mL) | 1.12 (0.83–1.63) | 2.27 (1.32–4.43) | < 0.001 |
cTnI (ng/mL) | 0.006 (0.006–0.014) | 0.027 (0.010–0.193) | < 0.001 |
Complications | |||
ARDS | 56 (25.9%) | 32 (35.2%) | 0.102 |
Acute cardiac injury | 23/215 (10.7%) | 43/91 (47.3%) | < 0.001 |
With history of cardiovascular disease | 19/108 (17.6%) | 37/70 (52.9%) | < 0.001 |
Without history of cardiovascular disease | 4/107 (3.7%) | 6/21 (28.6%) | 0.001 |
Heart failure (elevated BNP) | 21/185 (11.4%) | 18/84 (21.4%) | 0.030 |
New or worsening arrhythmia | 54 (25.0%) | 17 (18.7%) | 0.230 |
Acute liver injury | 20 (9.3%) | 15 (16.5%) | 0.069 |
Acute kidney injury | 4 (1.9%) | 9 (9.9%) | 0.004 |
Skeletal muscle injury | 9/204 (4.4%) | 11/81 (13.6%) | 0.006 |
Clinical outcome | |||
Discharge | 191 (88.4%) | 59 (64.8%) | < 0.001 |
Death | 25 (11.6%) | 32 (35.2%) |