Variable | All patients | Appropriate GLT | GLT Overtreatment | GLT Undertreatment | p-value |
---|---|---|---|---|---|
n = 318 | n = 79 (24.8%) | n = 182 (57.2%) | n = 57 (17.9%) | ||
Median [P25; P75] or n (%) | Median [P25; P75] or n (%) | Median [P25; P75] or n (%) | Median [P25; P75] or n (%) | ||
Age, in years | 84 [80; 88] | 84 [80; 87] | 84 [81; 88] | 83 [80; 87] | 0.544 |
Female | 146 (45.9) | 34 (43.0) | 89 (48.9) | 23 (40.4) | 0.443 |
Overall health category | |||||
Intermediate overall health | 105 (33.0) | 33 (41.8) | 52 (28.6) | 20 (35.1) | 0.107 |
Poor overall health | 213 (67.0) | 46 (58.2) | 130 (71.4) | 37 (64.9) | |
Comorbidities | |||||
Ischaemic heart disease | 136 (42.8) | 29 (36.7) | 77 (42.3) | 30 (52.6) | 0.177 |
Renal failure (n = 303)a | 51 (16.8) | 6 (7.9) | 36 (21.1) | 9 (16.1) | 0.038 |
Geriatric features | |||||
Nursing home residency | 71 (22.3) | 18 (22.8) | 45 (24.7) | 8 (14.0) | 0.238 |
Functional impairment b | 201 (63.2) | 44 (56.7) | 123 (67.6) | 34 (59.6) | 0.155 |
Severe polypharmacy c | 139 (43.7) | 33 (48.8) | 82 (45.1) | 24 (42.1) | 0.855 |
Cognitive impairment | 183 (57.5) | 46 (58.2) | 106 (58.2) | 33 (57.9) | 0.999 |
Recent falls | 169 (53.1) | 43 (54.4) | 93 (51.1) | 33 (57.9) | 0.646 |
Malnutrition | 96 (30.2) | 28 (35.4) | 52 (28.6) | 16 (28.1) | 0.501 |
GLT characteristics | |||||
HbA1c, in % | 6.9 [6.1; 7.8] | 6.8 [6.1; 7.6] | 6.7 [6.1; 7.2] | 9.2 [8.6; 10.1] | < 0.001 |
Use of GLT classes | |||||
Metformin | 131 (41.2) | 66 (83.5) | 46 (25.3) | 19 (33.3) | < 0.001 |
Other NHGAd | 9 (2.8) | 5 (6.3) | 3 (1.6) | 1 (1.8) | 0.101 |
Hypoglycaemic agents | 253 (79.6) | 20 (25.3) | 182 (100.0) | 51 (89.5) | < 0.001 |
Bi- or tri-therapy | 78 (24.5) | 12 (15.2) | 49 (26.9) | 17 (29.8) | 0.076 |
GLT total intensity, in DDD | 0.9 [0.5; 1.4] | 0.8 [0.4; 1.0] | 0.8 [0.5; 1.3] | 1.2 [0.8; 2.0] | 0.014 |
0–0.4 DDD | 73 (23.0) | 27 (34.2) | 40 (22.0) | 6 (10.5) | |
0.5–0.9 DDD | 103 (32.4) | 29 (36.7) | 58 (31.9) | 16 (28.1) | 0.002 |
≥ 1 DDD | 142 (44.7) | 23 (29.1) | 84 (46.2) | 35 (61.4) |