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Table 6 Study procedure with timelines

From: Train the brain with music (TBM): brain plasticity and cognitive benefits induced by musical training in elderly people in Germany and Switzerland, a study protocol for an RCT comparing musical instrumental practice to sensitization to music

RECRUITEMENT & PRE-screening
 Months Stage What Where Action Duration
 MONTH 1–3 Preparatory phase Recruitment of participants (n = ~ 70 in GE; n = ~ 100 in HA, on a total of ~  500 applications) according to exclusion/exclusion criteria
Detailed preparation of Behavioral Battery (psychometric testing) &
(f)MRI protocols
Local journals/
elderly journals/
flyers/presentations
HEdS-GE2 & IMMM3
BBL5 / HMS6
Announcements (press & flyers)
Presentations1/1rst check by telephone
Creation of E-prime4 programs; preparation of paper and pencil tests;
Synchronization of protocols between MRI scanners in Geneva and Hannover
 
 Month 4   Piloting of (f)MRI protocols (N = 20) & Behavioral Battery (N = 10) on non-included elderly individuals BBL / HEdS-GE / HMS / IMMM Feasibility testing  
  Pre-screening Step 1 See Table 2 At home Send/receive (mail/post) 60 min.
 Month 5–6 Pre-screening Step 2 (N GE = 63, N HA = 92) Check/completion of questionnaires of Step 1
Basic clinical audition test
Psychometric tests
i. Right-handedness
ii. COGTEL
HEdS-GE/ IMMM Come to HEdS-GE, IMMM 1x 20 min.
2 min.
5 min.
15 min.
After inclusion in the study
 Month 7–10   Recruitment and training of music teachers
Preparing of music education materials
   
  t0/baseline i. Behavioral Battery (psychometric testing)
ii. (f)MRI measurements
iii. Blood sampling (by registered nurse)
HEdS-GE / IMMM
BBL / HMS
HEdS-GE / IMMM
Come to HEdS-GE, IMMM 1x
Come to BBL, HMS 1x
Come to HEdS-GE, HMS 1x
2.5 h7
1.5 h
10 min.
 Month 10–22 Interventions 12 months of 1 h weekly music courses &
homework
HEdS-GE / IMMM
At home
HEdS-GE / IMMM
Practice daily at home
1 h/week
5 × 30 min./week
 MONTH 16 t1/ after 6 months of intervention i. Behavioral Battery (psychometric testing)
ii. (f)MRI measurements
iii. Blood sampling
HEdS-GE / IMMM
BBL / HMS
HEdS-GE / HMS
Come to HEdS-GE, IMMS 1x
Come to BBL, HMS 1x
2.5 h
1.5 h
10 min.
 Month 22 t2/directly after intervention completion i. Behavioral Battery (psychometric testing)
ii. COGTEL
iii. (f)MRI measurements
iv. Blood sampling
v. Food Frequency Questionnaire
vi. Cognitive reserve index1 (CRIq)8 [116]
HEdS-GE / IMMM
HEdS-GE / IMMM
BB / HMS
HEdS-GE / HMS
At home
HEdS-GE / IMMM
Come to HEdS-GE, IMMM 1x
(same session as Behavioral Battery)
Come to BBL, HMS 1x
Come to HEdS-GE, HMS 1x
Send (mail/post)
Come to HEdS-GE, IMMM 1x
2.5 h
15 min.
1.5 h
10 min.
30 min.
15 min.
Month 23–26 Cope with Delays, Analyses & Publications, Congress Attending
Month 27 t3/6 months after intervention completion i. Behavioral Battery (psychometric testing)
ii. (f)MRI measurements
iii. Blood sampling
HEdS-GE / IMMM
BBL / HMS
HEdS-GE / HMS
Come to HEdS-GE, IMMM 1x
Come to BBL, HMS 1x
Come to HEdS-GE, HMS1x
2.5 h
1.5 h
10 min.
Month 28–36 Cope with Delays, Analyses & Publications, Congress Attending
  1. 1Presentations at Cité Séniors Genève (http://www.ville-geneve.ch/themes/social/seniors/cite-seniors/); at the HEdS-GE2 and in Hannover at the HMTMH (Hannover University of Music Drama and Media)
  2. 2 HEdS-GE Haute école de Genève, 47 av. de Champel 47, 1206 Genève
  3. 3 Institute of Music Physiology and Musicians’ Medecine, Hannover, part of the HMTMH
  4. 4 Presentation soft-ware (https://pstnet.com/products/e-prime/)
  5. 5 Brain and Behaviour Laboratory (BBL, http://bbl.unige.ch/) , University Medical Centre of the University of Geneva
  6. 6 Hannover Medical School
  7. 7 During the Behavioral Battery several short breaks are included
  8. 8 This test has been added posteriorly