Table 5 MRI^a measurements (measured at all 4 time points: t0: baseline; t1: 6 months; t2: 12 months & t3: 18 months)

Grey matter volume assessment [108]

MP2RAGE^b; duration: 8.22 min; voxel size: 1 mm isotropic; 176 slices; FOV^c: 256x240x176 mm; TR^d/TE^e: 5000/2.98 ms; TI1^f/TI2^g: 700/2500 ms; flip angle 1/2: 4/5 degrees

Functional MRI

Tonal working memory task [109]

EPI^h; duration: 20.00 min; voxel size: 2.5 mm isotropic; 54 slices; FOV: 210x210x135 mm; multiband accelerator factor: 3; TR/TE: 1350/31.6 ms

Resting state functional MRI

Allows to measure activity in the Default Mode Network (DMN) reflecting global functional connectivity of the brain [110]

EPI; duration: 10.31 min; voxel size: 2.5 mm isotropic; 54 slices; FOV: 210x210x135 mm; multiband accelerator factor: 3; TR/TE: 1350/31.6 ms

White matter assessment

Allows to compute i.a. Fractional Anisotropy for evaluating white matter integrity reflecting structural connectivity [111].

DTIⁱ; duration 7.38 min; voxel size: 1.5 mm isotropic; 84 slices; FOV: 222x222x126 mm; multiband accelerator factor: 3; TR/TE: 5163/109.2 ms; b-values: 0/1500 s/mm²; 65 directions, anterior to posterior phase encoding direction followed by a reverse direction for distortion correction; b-values: 0/ s/mm²)

Blood perfusion assessment [112]

ASL^j; duration 6.10 min; voxel size: 2.5 × 2.5 × 3.0 mm; 36 slices; FOV: 220x220x129 mm; TR/TE: 3640/21.0 ms; flip angle: 90 degrees