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Table 5 MRIa measurements (measured at all 4 time points: t0: baseline; t1: 6 months; t2: 12 months & t3: 18 months)

From: Train the brain with music (TBM): brain plasticity and cognitive benefits induced by musical training in elderly people in Germany and Switzerland, a study protocol for an RCT comparing musical instrumental practice to sensitization to music

TYPE OF MRI MEASUREMENT / SCAN Main technical details of the Siemens protocols
Grey matter volume assessment [108] MP2RAGEb; duration: 8.22 min; voxel size: 1 mm isotropic; 176 slices; FOVc: 256x240x176 mm; TRd/TEe: 5000/2.98 ms; TI1f/TI2g: 700/2500 ms; flip angle 1/2: 4/5 degrees
Functional MRI
Tonal working memory task [109]
EPIh; duration: 20.00 min; voxel size: 2.5 mm isotropic; 54 slices; FOV: 210x210x135 mm; multiband accelerator factor: 3; TR/TE: 1350/31.6 ms
Resting state functional MRI
Allows to measure activity in the Default Mode Network (DMN) reflecting global functional connectivity of the brain [110]
EPI; duration: 10.31 min; voxel size: 2.5 mm isotropic; 54 slices; FOV: 210x210x135 mm; multiband accelerator factor: 3; TR/TE: 1350/31.6 ms
White matter assessment
Allows to compute i.a. Fractional Anisotropy for evaluating white matter integrity reflecting structural connectivity [111].
DTIi; duration 7.38 min; voxel size: 1.5 mm isotropic; 84 slices; FOV: 222x222x126 mm; multiband accelerator factor: 3; TR/TE: 5163/109.2 ms; b-values: 0/1500 s/mm2; 65 directions, anterior to posterior phase encoding direction followed by a reverse direction for distortion correction; b-values: 0/ s/mm2)
Blood perfusion assessment [112] ASLj; duration 6.10 min; voxel size: 2.5 × 2.5 × 3.0 mm; 36 slices; FOV: 220x220x129 mm; TR/TE: 3640/21.0 ms; flip angle: 90 degrees
  1. a MRI: Magnetic Resonance Imaging
  2. b MP2RAGE: Magnetization-Prepared 2 Rapid Acquisition Gradient Echoes
  3. c FOV: Field Of View
  4. d TR: Time to Repetition
  5. e TE: Time to Echo
  6. f TI1: Inversion Time 1
  7. g TI2; Inversion Time 2
  8. h EPI: Echo Planar Imaging
  9. i DTI: Diffusion Tensor Imaging
  10. j ASL: Arterial Spin Labeling