Table 2 Underlying and Direct Causes of Death among People with AD Stratified by Age at AD Diagnosis
From: Causes of death in a nationwide cohort of community-dwellers with Alzheimer’s disease
Category | ICD-10 code | < 65 years n = 409 | ≥65 years n = 20,061 | OR (95%CI |
|---|---|---|---|---|
Diseases of the circulatory system | I* | 48 (11.7) | 6436 (32.1) | 3.55 (2.47–4.62) |
Diseases of the nervous system | G* | 293 (71.6) | 9925 (49.5) | 0.38 (0.30–0.47) |
Neoplasms | C*, D00-D48 | 18 (4.4) | 1555 (7.8) | 1.82 (0.96–2.69) |
Mental and behavioral disorders | F* | 12 (2.9) | 413 (2.1) | 0.69 (0.29–1.10) |
Diseases of the respiratory system | J* | 5 (1.2) | 375 (1.9) | 1.54 (0.17–2.90) |
External causes of morbidity and mortality | V*, W*, X*, Y* | 10 (2.4) | 508 (2.5) | 1.03 (0.38–1.69) |
Diseases of the digestive system | K* | 6 (1.5) | 417 (2.1) | 1.42 (0.27–2.58) |
Certain infectious and parasitic diseases | A*, B* | 0 (0) | 96 (0.5) | N. A |
Diseases of the genitourinary system | N* | 1 (0.2) | 155 (0.8) | 3.17 (0.01–9.41) |
Endocrine, nutritional and metabolic diseases | E* | 4 (1.0) | 112 (0.6) | 0.57 (0.00–1.14) |
Diseases of the musculoskeletal system and connective tissue | M* | 1 (0.2) | 20 (0.1) | 0.41 (0.00–1.22) |
Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism | D50-D89 | 0 (0) | 11 (0.1) | N. A |
Symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified | R* | 1 (0.2) | 16 (0.1) | 0.33 (0.01–0.98) |
Congenital malformations, deformations and chromosomal abnormalities | Q* | 9 (2.2) | 4 (< 0.1) | 0.01 (0.00–0.02) |
Diseases of the skin and subcutaneous tissue | L* | 0 (0) | 4 (< 0.01) | N. A |