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Table 1 Underlying and Direct Causes of Death in the Comparison (No AD) and AD Cohorts of the MEDALZ-2005 Study

From: Causes of death in a nationwide cohort of community-dwellers with Alzheimer’s disease

Category

ICD-10 code

No AD, n = 10,171

AD, n = 20,470

OR (95%CI

Diseases of the circulatory system

I*

5441 (53.5)

6484 (31.7)

0.40 (0.38, 0.42)

Diseases of the nervous system

G*

440 (4.3)

10,218 (50.0)

22.06 (19.87, 24.25)

Neoplasms

C*, D00-D48

1942 (19.1)

1573 (7.7)

0.35 (0.33, 0.38)

Mental and behavioral disorders

F*

741 (7.3)

425 (2.1)

0.27 (0.24, 0.30)

Diseases of the respiratory system

J*

512 (5.0)

380 (1.9)

0.36 (0.31, 0.40)

External causes of morbidity and mortality

V*, W*, X*, Y*

356 (3.5)

518 (2.5)

0.72 (0.62, 0.81)

Diseases of the digestive system

K*

308 (3.0)

423 (2.1)

0.68 (0.58, 0.78)

Certain infectious and parasitic diseases

A*, B*

89 (0.9)

96 (0.5)

0.53 (0.40, 0.71)

Diseases of the genitourinary system

N*

132 (1.3)

156 (0.8)

0.58 (0.46, 0.74)

Endocrine, nutritional and metabolic diseases

E*

115 (1.1)

116 (0.6)

0.50 (0.38, 0.65)

Diseases of the musculoskeletal system and connective tissue

M*

49 (0.5)

21 (0.1)

0.21 (0.13, 0.35)

Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism

D50-D89

10 (0.1)

11 (0.1)

0.55 (0.23, 1.29)

Symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified

R*

10 (0.1)

17 (0.1)

0.84 (0.39, 1.85)

Congenital malformations, deformations and chromosomal abnormalities

Q*

8 (0.1)

13 (0.1)

0.81 (0.33, 1.95)

Diseases of the skin and subcutaneous tissue

L*

9 (0.1)

4 (< 0.1)

0.22 (0.07, 0.72)

Diseases of the eye, adnexa, ear and mastoid process

H*

2 < (0.1)

0 (0.0)

N.A