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Table 3 Univariate and multivariate analyses for one-year mortality, model for MPI-groups (n = 433)

From: Comprehensive geriatric assessment in older patients with cancer: an external validation of the multidimensional prognostic index in a French prospective cohort study

Variable HR (95% CI) P-value Adjusted HR (95% CI) P
ADL score (+ 1 point) 0.82 (0.74–0.91) 0.0003  
IADL score (+ 1 point) 0.85 (0.80–0.90) < 0.0001  
SPMSQ score (+ 1 point) 1.00 (0.92–1.09) 0.9577  
CIRS score (+ 1 point) 1.09 (1.05–1.13) < 0.0001  
MNA score (+ 1 point) 0.78 (0.73–0.82) < 0.0001  
ESS score (+ 1 point) 0.88 (0.84–0.93) < 0.0001  
Number of drugs (+ 1 drug) 1.05 (1.00–1.11) 0.0463  
Living status    
 living with family reference 0.6817   
 living alone 1.02 (0.69–1.51)   
 Institutionalized 1.27 (0.74–2.17)   
Age (+ 1 year) 1.01 (0.98–1.05) 0.4937 0.99 (0.95–1.02) 0.5149
Sex (male vs female) 0.95 (0.68–1.33) 0.7500 0.18 (0.06–0.57) 0.0035
Metastatic status 2.01 (1.43–2.81) <.0001 2.46 (1.72–3.53) <.0001
Tumor sites
 Colorectal reference < 0.0001 reference < 0.0001
 breast 0.79 (0.37–1.71) 0.14 (0.05–0.38)  
 prostate 0.27 (0.11–0.67) 0.59 (0.21–1.65)  
 Upper gastrointestinal tract/liver 0.18 (0.08–0.41) 0.75 (0.37–1.52)  
 urinary system 1.43 (0.55–3.73) 0.42 (0.18–1)  
 hematologic malignancies 1.15 (0.61–2.16) 0.46 (0.21–0.99)  
 other tumors 1.1 (0.62–1.97) 0.23 (0.1–0.55)  
Multidimensional Prognostic Index
 group 1 reference < 0.0001 reference < 0.0001
 group 2 2.19 (1.53–3.14) 2.06 (1.42–2.98)  
 group 3 3.65 (2.08–6.4) 4.34 (2.41–7.82)  
  1. Abbreviations: HR hazard ratio, CI confidence interval, MPI Multidimensional Prognostic Index
  2. Multivariate model adjusted for age, sex, tumor site, metastatic status and MPI groups