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Table 3 Univariate and multivariate analyses for one-year mortality, model for MPI-groups (n = 433)

From: Comprehensive geriatric assessment in older patients with cancer: an external validation of the multidimensional prognostic index in a French prospective cohort study

Variable

HR (95% CI)

P-value

Adjusted HR (95% CI)

P

ADL score (+ 1 point)

0.82 (0.74–0.91)

0.0003

 

IADL score (+ 1 point)

0.85 (0.80–0.90)

< 0.0001

 

SPMSQ score (+ 1 point)

1.00 (0.92–1.09)

0.9577

 

CIRS score (+ 1 point)

1.09 (1.05–1.13)

< 0.0001

 

MNA score (+ 1 point)

0.78 (0.73–0.82)

< 0.0001

 

ESS score (+ 1 point)

0.88 (0.84–0.93)

< 0.0001

 

Number of drugs (+ 1 drug)

1.05 (1.00–1.11)

0.0463

 

Living status

  

 

 living with family

reference

0.6817

  

 living alone

1.02 (0.69–1.51)

  

 Institutionalized

1.27 (0.74–2.17)

  

Age (+ 1 year)

1.01 (0.98–1.05)

0.4937

0.99 (0.95–1.02)

0.5149

Sex (male vs female)

0.95 (0.68–1.33)

0.7500

0.18 (0.06–0.57)

0.0035

Metastatic status

2.01 (1.43–2.81)

<.0001

2.46 (1.72–3.53)

<.0001

Tumor sites

 Colorectal

reference

< 0.0001

reference

< 0.0001

 breast

0.79 (0.37–1.71)

0.14 (0.05–0.38)

 

 prostate

0.27 (0.11–0.67)

0.59 (0.21–1.65)

 

 Upper gastrointestinal tract/liver

0.18 (0.08–0.41)

0.75 (0.37–1.52)

 

 urinary system

1.43 (0.55–3.73)

0.42 (0.18–1)

 

 hematologic malignancies

1.15 (0.61–2.16)

0.46 (0.21–0.99)

 

 other tumors

1.1 (0.62–1.97)

0.23 (0.1–0.55)

 

Multidimensional Prognostic Index

 group 1

reference

< 0.0001

reference

< 0.0001

 group 2

2.19 (1.53–3.14)

2.06 (1.42–2.98)

 

 group 3

3.65 (2.08–6.4)

4.34 (2.41–7.82)

 
  1. Abbreviations: HR hazard ratio, CI confidence interval, MPI Multidimensional Prognostic Index
  2. Multivariate model adjusted for age, sex, tumor site, metastatic status and MPI groups