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Table 2 Patients’ baseline characteristics and evaluation by multidimensional prognostic index MPI (n = 433)

From: Comprehensive geriatric assessment in older patients with cancer: an external validation of the multidimensional prognostic index in a French prospective cohort study

  Total cohort MPI-1 MPI-2 MPI-3 P
N = 433 N = 231 N = 172 N = 30
Sociodemographic characteristics
Age 82.8 ± 4.8 82.1 ± 4.5 83.5 ± 5.0 83.9 ± 5.7  0.007
Female n (%) 181 (42%) 82 (35%) 83 (48%) 16 (53%) 0.02
Oncological characteristics
Most frequent tumor sites 0.02
  Prostate 98 (23%) 75 (32%) 20 (12%) 3 (10%)
  Skin 72 (17%) 38 (16%) 26 (15%) 8 (3%)
  Colorectum 66 (15%) 34 (15%) 28 (16%) 4 (13%)
  Breast 52 (12%) 26 (11%) 23 (13%) 3 (10%)
  Hematological malignancies 37 (9%) 12 (5%) 24 (14%) 4 (13%)
  Bladder 34 (8%) 17 (7%) 14 (8%) 3 (10%)
Metastatic status n (%) 125 (29%) 70 (30%) 48 (28%) 7 (23%) 0.70
Type of antineoplastic treatment a 0.07
  Chemotherapy 162 (37%) 80 (35%) 72 (42%) 10 (33%)
  Surgery 137 (32%) 73 (32%) 48 (28%) 16 (53%)
  Radiotherapy 109 (25%) 72 (31%) 35 (20%) 2 (7%)
  Hormone therapy 32 (7%) 24 (10%) 8 (5%) 0
Comprehensive geriatric assessment and multidimensional prognostic index b
ADL score 5.2 ± 1.3 5.7 ± 0.6 5.1 ± 1.2 2.2 ± 1.4 < 0.0001
ADL category 364/42/27 226/4/1 135/29/8 3/9/18 < 0.0001
IADL score 5.1 ± 2.6 6.4 ± 1.7 4.2 ± 2.5 0.9 ± 1.0 < 0.0001
IADL category 221/95/117 165/54/12 56/41/75 0/0/30 < 0.0001
ESS score 17.8 ± 2.4 18.9 ± 1.4 17.1 ± 2.4 13.1 ± 2.3 < 0.0001
ESS category 330/62/41 198/4/29 129/33/10 3/25/2 < 0.0001
MNA-SF score 9.3 ± 2.9 10.5 ± 2.4 8.1 ± 2.7 6.0 ± 2.1 < 0.0001
MNA-SF category 102/204/127 90/117/24 11/83/78 1/4/25 < 0.0001
SPMSQ score 1.6 ± 2.0 1.1 ± 1.4 1.8 ± 2.1 4.5 ± 3.0 < 0.0001
SPMSQ category 372/44/9 220/7/1 141/25/3 11/12/7 < 0.0001
CIRS score 7.4 ± 4.2 6.2 ± 3.5 8.3 ± 3.8 12.2 ± 6.0 < 0.0001
CIRS-CI score 2.8 ± 1.7 2.2 ± 1.5 3.1 ± 1.5 4.5 ± 2.4 < 0.0001
CIRS-CI category 21/196/216 19/132/80 2/58/112 0/6/24 < 0.0001
Number of medications 6.7 ± 3.1 5.8 ± 3.0 7.6 ± 2.7 9.2 ± 3.2 < 0.0001
Number of medications category 55/162/215 48/107/76 7/50/114 0/5/25 < 0.0001
Living status (family/institution/alone) 263/43/115 186/5/33 71/23/73 6/15/9 < 0.0001
MPI score 0.393 ± 0.394 0.252 ± 0.225 0.494 ± 0.337 0.902 ± 0.871 < 0.0001
  1. Numbers are mean ± SD or n (%)
  2. Abbreviations: MPI multidimensional prognostic index, SD standard deviation, ADL activities of daily livings, IADL instrumental activities of daily livings, ESS Exton-Smith Scale, MNA-SF mini nutritional assessment short form, SPSMQ Short Portable Mental Status Questionnaire, CIRS Cumulative Illness Rating Scale, CI comorbidity index
  3. a Antineoplastic treatment may combine one or several types of treatment
  4. b Categories are reported as number of patients with no/minor/severe problem to calculate MPI score