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Table 2 Patients’ baseline characteristics and evaluation by multidimensional prognostic index MPI (n = 433)

From: Comprehensive geriatric assessment in older patients with cancer: an external validation of the multidimensional prognostic index in a French prospective cohort study

 

Total cohort

MPI-1

MPI-2

MPI-3

P

N = 433

N = 231

N = 172

N = 30

Sociodemographic characteristics

Age

82.8 ± 4.8

82.1 ± 4.5

83.5 ± 5.0

83.9 ± 5.7 

0.007

Female n (%)

181 (42%)

82 (35%)

83 (48%)

16 (53%)

0.02

Oncological characteristics

Most frequent tumor sites

0.02

 

Prostate

98 (23%)

75 (32%)

20 (12%)

3 (10%)

 

Skin

72 (17%)

38 (16%)

26 (15%)

8 (3%)

 

Colorectum

66 (15%)

34 (15%)

28 (16%)

4 (13%)

 

Breast

52 (12%)

26 (11%)

23 (13%)

3 (10%)

 

Hematological malignancies

37 (9%)

12 (5%)

24 (14%)

4 (13%)

 

Bladder

34 (8%)

17 (7%)

14 (8%)

3 (10%)

Metastatic status n (%)

125 (29%)

70 (30%)

48 (28%)

7 (23%)

0.70

Type of antineoplastic treatment a

0.07

 

Chemotherapy

162 (37%)

80 (35%)

72 (42%)

10 (33%)

 

Surgery

137 (32%)

73 (32%)

48 (28%)

16 (53%)

 

Radiotherapy

109 (25%)

72 (31%)

35 (20%)

2 (7%)

 

Hormone therapy

32 (7%)

24 (10%)

8 (5%)

0

Comprehensive geriatric assessment and multidimensional prognostic index b

ADL score

5.2 ± 1.3

5.7 ± 0.6

5.1 ± 1.2

2.2 ± 1.4

< 0.0001

ADL category

364/42/27

226/4/1

135/29/8

3/9/18

< 0.0001

IADL score

5.1 ± 2.6

6.4 ± 1.7

4.2 ± 2.5

0.9 ± 1.0

< 0.0001

IADL category

221/95/117

165/54/12

56/41/75

0/0/30

< 0.0001

ESS score

17.8 ± 2.4

18.9 ± 1.4

17.1 ± 2.4

13.1 ± 2.3

< 0.0001

ESS category

330/62/41

198/4/29

129/33/10

3/25/2

< 0.0001

MNA-SF score

9.3 ± 2.9

10.5 ± 2.4

8.1 ± 2.7

6.0 ± 2.1

< 0.0001

MNA-SF category

102/204/127

90/117/24

11/83/78

1/4/25

< 0.0001

SPMSQ score

1.6 ± 2.0

1.1 ± 1.4

1.8 ± 2.1

4.5 ± 3.0

< 0.0001

SPMSQ category

372/44/9

220/7/1

141/25/3

11/12/7

< 0.0001

CIRS score

7.4 ± 4.2

6.2 ± 3.5

8.3 ± 3.8

12.2 ± 6.0

< 0.0001

CIRS-CI score

2.8 ± 1.7

2.2 ± 1.5

3.1 ± 1.5

4.5 ± 2.4

< 0.0001

CIRS-CI category

21/196/216

19/132/80

2/58/112

0/6/24

< 0.0001

Number of medications

6.7 ± 3.1

5.8 ± 3.0

7.6 ± 2.7

9.2 ± 3.2

< 0.0001

Number of medications category

55/162/215

48/107/76

7/50/114

0/5/25

< 0.0001

Living status (family/institution/alone)

263/43/115

186/5/33

71/23/73

6/15/9

< 0.0001

MPI score

0.393 ± 0.394

0.252 ± 0.225

0.494 ± 0.337

0.902 ± 0.871

< 0.0001

  1. Numbers are mean ± SD or n (%)
  2. Abbreviations: MPI multidimensional prognostic index, SD standard deviation, ADL activities of daily livings, IADL instrumental activities of daily livings, ESS Exton-Smith Scale, MNA-SF mini nutritional assessment short form, SPSMQ Short Portable Mental Status Questionnaire, CIRS Cumulative Illness Rating Scale, CI comorbidity index
  3. a Antineoplastic treatment may combine one or several types of treatment
  4. b Categories are reported as number of patients with no/minor/severe problem to calculate MPI score
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BMC Geriatrics

ISSN: 1471-2318

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