Table 4 Adjusted odds ratios for incident dementia according to anticholinergic burden measured using KABS and ACB with and without weak anticholinergics
Including medications with score 1 | Excluding medications with score 1 | |||
|---|---|---|---|---|
KABS aORa (95% CI) | ACB aORa (95% CI) | KABS-1 aORa (95% CI) | ACB-1 aORa (95% CI) | |
Anticholinergic exposure during 2–10 years before index year | ||||
Minimal (< 0.25) | reference | reference | reference | reference |
Low (0.25–1) | 1.21 (1.17–1.25) | 1.06 (1.04–1.10) | 1.23 (1.19–1.28) | 1.24 (1.19–1.29) |
Intermediate (1–2) | 1.39 (1.31–1.46) | 1.10 (1.04–1.15) | 1.45 (1.36–1.56) | 1.42 (1.30–1.56) |
High (≥2) | 1.71 (1.55–1.87) | 1.22 (1.12–1.33) | 1.60 (1.38–1.86) | 1.41 (1.14–1.75) |
Anticholinergic exposure during 5–10 years before index year | ||||
Minimal (< 0.25) | reference | reference | reference | reference |
Low (0.25–1) | 1.14 (1.10–1.18) | 1.00 (0.96–1.03) | 1.17 (1.13–1.21) | 1.22 (1.17–1.28) |
Intermediate (1–2) | 1.27 (1.20–1.35) | 1.02 (0.97–1.08) | 1.33 (1.24–1.44) | 1.38 (1.24–1.54) |
High (≥2) | 1.44 (1.30–1.59) | 1.09 (0.99–1.19) | 1.35 (1.15–1.58) | 1.23 (0.97–1.56) |