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Table 1 Prevalence of potentially inappropriate medications in elderly (≥70 years) MDD users in Norway

From: Potentially inappropriate prescribing to older patients receiving multidose drug dispensing

  Study population
(n = 45,593)
Female
(n = 30,090)
Male
(n = 15,503)
Age 70–79
(n = 11,435)
Age 80–89
(n = 21,633)
Age 90+
(n = 12,525)
NORGEP single substance criteria n n n n n n
1. Amitriptyline 848 19 639 21 209 13 312 27 381 18 155 12
2. Doxepin 61 1 44 1 17 1 17 1 25 1 19 2
3. Clomipramine 74 2 64 2 10 1 31 3 33 2 10 1
4. Trimipramine 162 4 120 4 42 3 60 5 69 3 33 3
5. Chlorpromazine (withdrawn from Norw. market 2007) 5 0 5 0 0 0 4 0 1 0 0 0
6. Chlorprothixene 387 8 234 8 153 10 222 19 130 6 35 3
7. Levomepromazine 391 9 255 8 136 9 195 17 140 6 56 4
8. Prochlorperazine 288 6 230 8 58 4 59 5 133 6 96 8
9. Diazepam 2911 64 2175 72 736 47 1011 88 1269 59 631 50
10. trazepam 839 18 595 20 244 16 227 20 342 16 270 22
11. Flunitrazepam 15 0 12 0 3 0 7 1 4 0 4 0
12. Oxazepam > 30 mg/24 h 335 7 253 8 82 5 179 16 116 5 40 3
13. Zopiclone > 7.5 mg/24 h 142 3 98 3 44 3 65 6 52 2 25 2
14. Carisoprodol (withdrawn from Norw. market 2008) 1 0 0 0 1 0 0 0 1 0 0 0
15. Dextropropoxyphene (withdrawn from Norw. market 2009) 0 0 0 0 0 0 0 0 0 0 0 0
16. Theophylline 107 2 68 2 39 3 45 4 50 2 12 1
17. Sotalol 210 5 133 4 77 5 30 3 116 5 64 5
18. Dexchlorpheniramine 64 1 42 1 22 1 20 2 26 1 18 1
19. Promethazine 85 2 54 2 31 2 31 3 35 2 19 2
20. Hydroxyzine 766 17 472 16 294 19 252 22 306 14 208 17
21. Alimemazine/ trimeprazine 964 21 634 21 330 21 419 37 395 18 150 12
NORGEP combination criteria
22. Warfarin + NSAID 36 1 23 1 13 1 8 1 19 1 9 1
23. Warfarin + ofloxacin/ ciprofloxacin NOT ANALYZED: ANTIBIOTICS ARE NOT INCLUDED ON THE MDD PRESCRIPTIONS
24. Warfarin + erythromycin/ clarithromycin NOT ANALYZED: ANTIBIOTICS ARE NOT INCLUDED ON THE MDD PRESCRIPTIONS
25. Warfarin + SSRI 348 8 229 8 119 8 83 7 183 8 82 7
26. NSAID + ACE inhibitor/ARB 573 13 407 14 166 11 195 17 270 12 108 9
27. NSAID + diuretics 633 14 454 15 179 12 181 16 272 13 180 14
28. NSAID + glucocorticoids 206 5 160 5 46 3 68 6 98 5 40 3
29. NSAID + SSRI 370 8 309 10 61 4 139 12 174 8 57 5
30. Erythromycin/ clarithromycin + statin NOT ANALYZED: ANTIBIOTICS ARE NOT INCLUDED ON THE MDD PRESCRIPTIONS
31. ACE inhibitor+ potassium /potassium-sparing diuretic 1035 23 625 21 410 26 324 28 457 21 254 20
32. Fluoxetine/ fluvoxamine + TCA 3 0 2 0 1 0 2 0 1 0 0 0
33. Beta blocker + cardioselective calcium antagonist 147 3 107 4 40 3 28 2 67 3 52 4
34. Diltiazem + lovastatin/ simvastatin 34 1 22 1 12 1 13 1 15 1 6 0
35. Erythromycin/clarithromycin + carbamazepine NOT ANALYZED: ANTIBIOTICS ARE NOT INCLUDED ON THE MDD PRESCRIPTIONS
36. Concomitant prescription of three or more drugs from the groups centrally acting analgesics, antipsychotics, antidepressants, and/or benzodiazepines 4906 108 3775 125 1131 73 1959 171 2047 95 900 72