Any anticholinergic use | Potent anticholinergic use | |||||||
---|---|---|---|---|---|---|---|---|
Population | Prevalence % (95% CI) | Adjusted OR for CFAS II vs CFAS Ia | Prevalence % (95% CI) | Adjusted OR for CFAS II vs CFAS Ia | ||||
CFAS I | CFAS II | OR (95% CI) | pb | CFAS I | CFAS II | OR (95% CI) | pb | |
Overall | 49.6 (48.4, 50.7) | 64.3 (63.2, 65.4) | 1.25 (1.17, 1.34) | < 0.001 | 5.7 (5.2, 6.3) | 9.9 (9.3, 10.7) | 1.90 (1.67, 2.16) | < 0.001 |
By sex | ||||||||
Male | 46.7 (44.9, 48.6) | 61.3 (59.6, 62.9) | 1.00 | 0.06 | 3.6 (3.0, 4.4) | 6.4 (5.6,7.3) | 1.00 | 0.59 |
Female | 51.3 (49.8, 52.8) | 66.7 (65.2, 68.2) | 1.14 (0.99, 1.30) | 7.0 (6.3, 7.8) | 12.8 (11.7,13.9) | 1.08 (0.82, 1.43) | ||
By age, years | ||||||||
64–69 | 44.4 (42.2,46.6) | 53.5 (51.2,55.7) | 1.00 | < 0.001 | 5.2 (4.3,6.3) | 8.0 (6.8,9.5) | 1.00 | 0.49 |
70–74 | 48.2 (45.9,50.6) | 62.9 (60.7,65.1) | 1.33 (1.11, 1.60) | 5.9 (4.9,7.1) | 9.9 (8.6,11.4) | 1.11 (0.76, 1.60) | ||
75–79 | 52.8 (50.4,55.2) | 68.8 (66.4,71.0) | 1.41 (1.17, 1.71) | 6.0 (4.9,7.2) | 11.3 (9.7,13.0) | 1.28 (0.88, 1.86) | ||
80–84 | 54.3 (51.5,57.0) | 73.0 (70.4,75.5) | 1.48 (1.20, 1.82) | 6.8 (5.5,8.3) | 11.0 (9.3,12.9) | 1.09 (0.73, 1.62) | ||
85–89 | 53.8 (49.6,58.0) | 72.1 (68.5,75.5) | 1.58 (1.21, 2.07) | 5.3 (3.7,7.5) | 11.8 (9.5,14.6) | 1.59 (0.95, 2.69) | ||
90+ | 50.7 (43.5,57.8) | 75.5 (68.9,81.1) | 2.10 (1.36, 3.22) | 4.1 (2.0,8.0) | 9.0 (5.9,13.6) | 1.54 (0.63, 3.75) | ||
By cognition | ||||||||
MMSE ≤21 | 53.3 (49.0, 57.6) | 71.5 (65.0, 77.1) | 1.00 | 0.02 | 11.2 (8.6,14.4) | 16.5 (12.0, 22.3) | 1.00 | 0.83 |
MMSE 22–25 | 52.7 (50.2, 55.1) | 69.9 (67.1, 72.6) | 0.94 (0.70, 1.25) | 6.7 (5.6,8.1) | 13.4 (11.4,15.6) | 1.10 (0.71, 1.70) | ||
MMSE 26–30 | 48.6 (47.0, 50.2) | 62.8 (61.5, 64.1) | 0.76 (0.59, 0.99) | 4.5 (3.9,5.2) | 8.4 (7.7,9.2) | 1.00 (0.68, 1.49) | ||
By disability | ||||||||
No impairment | 42.4 (40.8,44.0) | 56.9 (55.4,58.5) | 1.00 | 0.27 | 3.8 (3.3, 4.5) | 6.3 (5.6, 7.1) | 1.00 | 0.05 |
IADL impairment | 67.1 (64.0,70.0) | 80.4 (78.1,82.5) | 1.13 (0.93, 1.36) | 6.8 (5.4, 8.7) | 15.8 (13.8, 18.0) | 1.46 (1.04, 2.04) | ||
ADL impairment | 71.1 (67.7,74.3) | 85.4 (82.3,88.1) | 1.15 (0.92, 1.43) | 15.8 (13.1,18.9) | 20.8 (17.6, 24.5) | 0.95 (0.70, 1.29) |