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Table 2 Prevalence of any and potent anticholinergic use in CFAS I and CFAS II, by age, sex, cognition and disability

From: Increasing prevalence of anticholinergic medication use in older people in England over 20 years: cognitive function and ageing study I and II

 

Any anticholinergic use

Potent anticholinergic use

Population

Prevalence % (95% CI)

Adjusted OR for CFAS II vs CFAS Ia

Prevalence % (95% CI)

Adjusted OR for CFAS II vs CFAS Ia

CFAS I

CFAS II

OR (95% CI)

pb

CFAS I

CFAS II

OR (95% CI)

pb

Overall

49.6 (48.4, 50.7)

64.3 (63.2, 65.4)

1.25 (1.17, 1.34)

< 0.001

5.7 (5.2, 6.3)

9.9 (9.3, 10.7)

1.90 (1.67, 2.16)

< 0.001

By sex

 Male

46.7 (44.9, 48.6)

61.3 (59.6, 62.9)

1.00

0.06

3.6 (3.0, 4.4)

6.4 (5.6,7.3)

1.00

0.59

 Female

51.3 (49.8, 52.8)

66.7 (65.2, 68.2)

1.14 (0.99, 1.30)

 

7.0 (6.3, 7.8)

12.8 (11.7,13.9)

1.08 (0.82, 1.43)

 

By age, years

 64–69

44.4 (42.2,46.6)

53.5 (51.2,55.7)

1.00

< 0.001

5.2 (4.3,6.3)

8.0 (6.8,9.5)

1.00

0.49

 70–74

48.2 (45.9,50.6)

62.9 (60.7,65.1)

1.33 (1.11, 1.60)

 

5.9 (4.9,7.1)

9.9 (8.6,11.4)

1.11 (0.76, 1.60)

 

 75–79

52.8 (50.4,55.2)

68.8 (66.4,71.0)

1.41 (1.17, 1.71)

 

6.0 (4.9,7.2)

11.3 (9.7,13.0)

1.28 (0.88, 1.86)

 

 80–84

54.3 (51.5,57.0)

73.0 (70.4,75.5)

1.48 (1.20, 1.82)

 

6.8 (5.5,8.3)

11.0 (9.3,12.9)

1.09 (0.73, 1.62)

 

 85–89

53.8 (49.6,58.0)

72.1 (68.5,75.5)

1.58 (1.21, 2.07)

 

5.3 (3.7,7.5)

11.8 (9.5,14.6)

1.59 (0.95, 2.69)

 

 90+

50.7 (43.5,57.8)

75.5 (68.9,81.1)

2.10 (1.36, 3.22)

 

4.1 (2.0,8.0)

9.0 (5.9,13.6)

1.54 (0.63, 3.75)

 

By cognition

 MMSE ≤21

53.3 (49.0, 57.6)

71.5 (65.0, 77.1)

1.00

0.02

11.2 (8.6,14.4)

16.5 (12.0, 22.3)

1.00

0.83

 MMSE 22–25

52.7 (50.2, 55.1)

69.9 (67.1, 72.6)

0.94 (0.70, 1.25)

 

6.7 (5.6,8.1)

13.4 (11.4,15.6)

1.10 (0.71, 1.70)

 

 MMSE 26–30

48.6 (47.0, 50.2)

62.8 (61.5, 64.1)

0.76 (0.59, 0.99)

 

4.5 (3.9,5.2)

8.4 (7.7,9.2)

1.00 (0.68, 1.49)

 

By disability

 No impairment

42.4 (40.8,44.0)

56.9 (55.4,58.5)

1.00

0.27

3.8 (3.3, 4.5)

6.3 (5.6, 7.1)

1.00

0.05

 IADL impairment

67.1 (64.0,70.0)

80.4 (78.1,82.5)

1.13 (0.93, 1.36)

 

6.8 (5.4, 8.7)

15.8 (13.8, 18.0)

1.46 (1.04, 2.04)

 

 ADL impairment

71.1 (67.7,74.3)

85.4 (82.3,88.1)

1.15 (0.92, 1.43)

 

15.8 (13.1,18.9)

20.8 (17.6, 24.5)

0.95 (0.70, 1.29)

 
  1. Weighted for nonresponse and standardised by the UK 2011 age population, missing cases excluded
  2. Abbreviations: CFAS Cognitive Function and Ageing Studies, CI confidence interval, MMSE Mini-Mental State Examination, ADL activities of daily living, IADL instrumental activities of daily living
  3. aAdjusted for age, sex and centre
  4. bGlobal test for the interaction between the covariate and difference in prevalence between CFAS I and CFAS II