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Table 2 Prevalence of any and potent anticholinergic use in CFAS I and CFAS II, by age, sex, cognition and disability

From: Increasing prevalence of anticholinergic medication use in older people in England over 20 years: cognitive function and ageing study I and II

  Any anticholinergic use Potent anticholinergic use
Population Prevalence % (95% CI) Adjusted OR for CFAS II vs CFAS Ia Prevalence % (95% CI) Adjusted OR for CFAS II vs CFAS Ia
CFAS I CFAS II OR (95% CI) pb CFAS I CFAS II OR (95% CI) pb
Overall 49.6 (48.4, 50.7) 64.3 (63.2, 65.4) 1.25 (1.17, 1.34) < 0.001 5.7 (5.2, 6.3) 9.9 (9.3, 10.7) 1.90 (1.67, 2.16) < 0.001
By sex
 Male 46.7 (44.9, 48.6) 61.3 (59.6, 62.9) 1.00 0.06 3.6 (3.0, 4.4) 6.4 (5.6,7.3) 1.00 0.59
 Female 51.3 (49.8, 52.8) 66.7 (65.2, 68.2) 1.14 (0.99, 1.30)   7.0 (6.3, 7.8) 12.8 (11.7,13.9) 1.08 (0.82, 1.43)  
By age, years
 64–69 44.4 (42.2,46.6) 53.5 (51.2,55.7) 1.00 < 0.001 5.2 (4.3,6.3) 8.0 (6.8,9.5) 1.00 0.49
 70–74 48.2 (45.9,50.6) 62.9 (60.7,65.1) 1.33 (1.11, 1.60)   5.9 (4.9,7.1) 9.9 (8.6,11.4) 1.11 (0.76, 1.60)  
 75–79 52.8 (50.4,55.2) 68.8 (66.4,71.0) 1.41 (1.17, 1.71)   6.0 (4.9,7.2) 11.3 (9.7,13.0) 1.28 (0.88, 1.86)  
 80–84 54.3 (51.5,57.0) 73.0 (70.4,75.5) 1.48 (1.20, 1.82)   6.8 (5.5,8.3) 11.0 (9.3,12.9) 1.09 (0.73, 1.62)  
 85–89 53.8 (49.6,58.0) 72.1 (68.5,75.5) 1.58 (1.21, 2.07)   5.3 (3.7,7.5) 11.8 (9.5,14.6) 1.59 (0.95, 2.69)  
 90+ 50.7 (43.5,57.8) 75.5 (68.9,81.1) 2.10 (1.36, 3.22)   4.1 (2.0,8.0) 9.0 (5.9,13.6) 1.54 (0.63, 3.75)  
By cognition
 MMSE ≤21 53.3 (49.0, 57.6) 71.5 (65.0, 77.1) 1.00 0.02 11.2 (8.6,14.4) 16.5 (12.0, 22.3) 1.00 0.83
 MMSE 22–25 52.7 (50.2, 55.1) 69.9 (67.1, 72.6) 0.94 (0.70, 1.25)   6.7 (5.6,8.1) 13.4 (11.4,15.6) 1.10 (0.71, 1.70)  
 MMSE 26–30 48.6 (47.0, 50.2) 62.8 (61.5, 64.1) 0.76 (0.59, 0.99)   4.5 (3.9,5.2) 8.4 (7.7,9.2) 1.00 (0.68, 1.49)  
By disability
 No impairment 42.4 (40.8,44.0) 56.9 (55.4,58.5) 1.00 0.27 3.8 (3.3, 4.5) 6.3 (5.6, 7.1) 1.00 0.05
 IADL impairment 67.1 (64.0,70.0) 80.4 (78.1,82.5) 1.13 (0.93, 1.36)   6.8 (5.4, 8.7) 15.8 (13.8, 18.0) 1.46 (1.04, 2.04)  
 ADL impairment 71.1 (67.7,74.3) 85.4 (82.3,88.1) 1.15 (0.92, 1.43)   15.8 (13.1,18.9) 20.8 (17.6, 24.5) 0.95 (0.70, 1.29)  
  1. Weighted for nonresponse and standardised by the UK 2011 age population, missing cases excluded
  2. Abbreviations: CFAS Cognitive Function and Ageing Studies, CI confidence interval, MMSE Mini-Mental State Examination, ADL activities of daily living, IADL instrumental activities of daily living
  3. aAdjusted for age, sex and centre
  4. bGlobal test for the interaction between the covariate and difference in prevalence between CFAS I and CFAS II