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Table 2 Treatment Effects Compared to Placebo in Primary Analyses of Randomized Trial Data: Fracture, Mortality, Cerebrovascular Event, and Fall

From: Safety of pharmacologic interventions for neuropsychiatric symptoms in dementia: a systematic review and network meta-analysis

Intervention
(vs. Placebo)
Bayesian NMA
OR Estimate
(95% CrI)
Frequentist NMA
OR Estimate
(95% CI)
Fracture (n = 29 RCTs, 13,410 patients, 133 events)
 Anticonvulsants0.11 (< 0.01 to 2.10)0.21 (0.01 to 4.34)
 Antidepressants0.16 (< 0.01 to 5.34)0.28 (0.01 to 7.4)
 Antipsychotics0.72 (0.33 to 1.66)0.64 (0.3 to 1.37)
 Cholinesterase Inhibitors1.34 (0.86 to 2.14)1.29 (0.81 to 2.04)
 Cholinesterase Inhibitors + Memantine6.63 (0.75 to 209.7)4.84 (0.51 to 46.35)
 Memantine0.58 (0.16 to 1.93)0.64 (0.16 to 2.64)
Mortality (n = 104 RCTs, 38,683 patients, 1037 events)
 Anticonvulsants1.29 (0.55 to 2.95)1.13 (0.48 to 2.64)
 Antidepressants0.83 (0.33 to 2.25)0.88 (0.36 to 2.16)
 Antipsychotics1.17 (0.87 to 1.6)1.14 (0.84 to 1.55)
 Cholinesterase Inhibitors0.82 (0.68 to 1)0.8 (0.65 to 0.98)
 Cholinesterase Inhibitors + Memantine0.85 (0.45 to 1.67)0.86 (0.44 to 1.65)
 Memantine1.08 (0.78 to 1.45)1.05 (0.77 to 1.44)
Cerebrovascular Event (n = 47 RCTs, 19,070 patients, 314 events)
 Anticonvulsants1.04 (0.1 to 11.39)1.03 (0.1 to 10.03)
 Antidepressants0.19 (< 0.01 to 5.85)0.32 (0.01 to 8.23)
 Antipsychotics2.23 (1.36 to 3.79)1.94 (1.15 to 3.27)
 Cholinesterase Inhibitors1.02 (0.72 to 1.48)1.01 (0.72 to 1.39)
 Cholinesterase Inhibitors + Memantine1.11 (0.29 to 3.8)0.99 (0.28 to 3.46)
 Dextromethorphan-Quinidine1.35 (0.03 to 55.23)1.37 (0.08 to 22.18)
 Memantine0.76 (0.45 to 1.29)0.74 (0.43 to 1.28)
Fall (n = 58 RCTs, 21,776 patients, 1751 events)
 Anticonvulsants1.31 (0.89 to 1.95)1.33 (0.94 to 1.87)
 Antidepressants1.06 (0.54 to 2.09)1.13 (0.55 to 2.32)
 Antipsychotics0.99 (0.79 to 1.23)0.98 (0.79 to 1.2)
 Cholinesterase Inhibitors0.93 (0.77 to 1.14)0.94 (0.78 to 1.13)
 Cholinesterase Inhibitors + Memantine0.97 (0.63 to 1.48)1.06 (0.68 to 1.66)
 Dextromethorphan-Quinidine4.24 (1.47 to 14.79)3.97 (1.36 to 11.55)
 Memantine0.95 (0.77 to 1.17)0.96 (0.79 to 1.18)
  1. Abbreviations: CrI credible interval, CI confidence interval, NMA network meta-analysis, n number, OR odds ratio, RCT randomized trial