Table 2 Treatment Effects Compared to Placebo in Primary Analyses of Randomized Trial Data: Fracture, Mortality, Cerebrovascular Event, and Fall
Intervention (vs. Placebo) | Bayesian NMA OR Estimate (95% CrI) | Frequentist NMA OR Estimate (95% CI) |
|---|---|---|
Fracture (n = 29 RCTs, 13,410 patients, 133 events) | ||
 Anticonvulsants | 0.11 (< 0.01 to 2.10) | 0.21 (0.01 to 4.34) |
 Antidepressants | 0.16 (< 0.01 to 5.34) | 0.28 (0.01 to 7.4) |
 Antipsychotics | 0.72 (0.33 to 1.66) | 0.64 (0.3 to 1.37) |
 Cholinesterase Inhibitors | 1.34 (0.86 to 2.14) | 1.29 (0.81 to 2.04) |
 Cholinesterase Inhibitors + Memantine | 6.63 (0.75 to 209.7) | 4.84 (0.51 to 46.35) |
 Memantine | 0.58 (0.16 to 1.93) | 0.64 (0.16 to 2.64) |
Mortality (n = 104 RCTs, 38,683 patients, 1037 events) | ||
 Anticonvulsants | 1.29 (0.55 to 2.95) | 1.13 (0.48 to 2.64) |
 Antidepressants | 0.83 (0.33 to 2.25) | 0.88 (0.36 to 2.16) |
 Antipsychotics | 1.17 (0.87 to 1.6) | 1.14 (0.84 to 1.55) |
 Cholinesterase Inhibitors | 0.82 (0.68 to 1) | 0.8 (0.65 to 0.98) |
 Cholinesterase Inhibitors + Memantine | 0.85 (0.45 to 1.67) | 0.86 (0.44 to 1.65) |
 Memantine | 1.08 (0.78 to 1.45) | 1.05 (0.77 to 1.44) |
Cerebrovascular Event (n = 47 RCTs, 19,070 patients, 314 events) | ||
 Anticonvulsants | 1.04 (0.1 to 11.39) | 1.03 (0.1 to 10.03) |
 Antidepressants | 0.19 (< 0.01 to 5.85) | 0.32 (0.01 to 8.23) |
 Antipsychotics | 2.23 (1.36 to 3.79) | 1.94 (1.15 to 3.27) |
 Cholinesterase Inhibitors | 1.02 (0.72 to 1.48) | 1.01 (0.72 to 1.39) |
 Cholinesterase Inhibitors + Memantine | 1.11 (0.29 to 3.8) | 0.99 (0.28 to 3.46) |
 Dextromethorphan-Quinidine | 1.35 (0.03 to 55.23) | 1.37 (0.08 to 22.18) |
 Memantine | 0.76 (0.45 to 1.29) | 0.74 (0.43 to 1.28) |
Fall (n = 58 RCTs, 21,776 patients, 1751 events) | ||
 Anticonvulsants | 1.31 (0.89 to 1.95) | 1.33 (0.94 to 1.87) |
 Antidepressants | 1.06 (0.54 to 2.09) | 1.13 (0.55 to 2.32) |
 Antipsychotics | 0.99 (0.79 to 1.23) | 0.98 (0.79 to 1.2) |
 Cholinesterase Inhibitors | 0.93 (0.77 to 1.14) | 0.94 (0.78 to 1.13) |
 Cholinesterase Inhibitors + Memantine | 0.97 (0.63 to 1.48) | 1.06 (0.68 to 1.66) |
 Dextromethorphan-Quinidine | 4.24 (1.47 to 14.79) | 3.97 (1.36 to 11.55) |
 Memantine | 0.95 (0.77 to 1.17) | 0.96 (0.79 to 1.18) |