mITT population (n = 69) | First visit | Last visit | Mean difference$ (95% CI) | Pvalue* |
---|---|---|---|---|
6-min walk test | (N = 51) | (N = 38) | (N = 54) | |
Distance | 213 ± 93 | 257 ± 79 | 23 (6 to 39) | 0.008 |
Predicted (%) | 59 ± 39 | 76 ± 38 | 8 (2 to 14) | 0.007 |
Spatio-temporal gait parameters | ||||
Usual pace | (N = 56) | (N = 38) | (N = 62) | |
Speed (cm/sec) | 56 ± 22 | 62 ± 20 | 4.6 (−0.8 to 10.0) | 0.093 |
Mean step length (cm) | 37 ± 10 | 39 ± 10 | 2.2 (0.0 to 4.4) | 0.048 |
Mean stride length (cm) | 74 ± 21 | 77 ± 20 | 3.6 (−1.3 to 8.5) | 0.142 |
Mean support base (cm) | 13 ± 4 | 14 ± 4 | − 0.1 (− 1.1 to 0.9) | 0.801 |
Mean double support time (msec) | 5.8 ± 2.3 | 5.1 ± 1.5 | − 0.5 (− 0.9 to 0.0) | 0.053 |
Maximum pace | (N = 57) | (N = 39) | (N = 61) | |
Speed (cm/sec) | 77 ± 31 | 85 ± 29 | 8.5 (3.6 to 13.4) | 0.001 |
Mean step length (cm) | 42 ± 13 | 45 ± 13 | 2.9 (0.7 to 5.1) | 0.011 |
Mean stride length (cm) | 85 ± 26 | 91 ± 26 | 6.0 (1.6 to 10.3) | 0.008 |
Mean support base (cm) | 13 ± 4 | 13 ± 4 | −0.7 (−1.6 to 0.2) | 0.105 |
Mean double support time (msec) | 4.3 ± 2.1 | 3.8 ± 1.4 | −0.3 (− 0.6 to − 0.1) | 0.013 |
Gait variability parameters | ||||
Usual pace | (N = 55) | (N = 38) | (N = 62) | |
CV step length | 13.2 ± 6.8 | 12.2 ± 6.1 | −0.7 (−3.0 to 1.5) | 0.503 |
CV step time | 8.8 ± 7.4 | 7.6 ± 2.9 | −0.4 (−1.7 to 0.8) | 0.502 |
CV stride length | 7.7 ± 4.0 | 7.5 ± 3.8 | − 0.1 (− 1.7 to 1.4) | 0.846 |
CV stride time | 5.7 ± 5.4 | 4.7 ± 2.0 | −0.4 (− 1.3 to 0.5) | 0.361 |
Maximum pace | (N = 57) | (N = 39) | (N = 61) | |
CV step length | 11.7 ± 7.5 | 11.6 ± 10.1 | 0.2 (−3.2 to 3.5) | 0.914 |
CV step time | 8.5 ± 8.6 | 6.7 ± 2.9 | −0.3 (−1.2 to 0.7) | 0.590 |
CV stride length | 6.7 ± 3.2 | 7.1 ± 5.5 | 0.4 (−1.2 to 2.0) | 0.613 |
CV stride time | 4.7 ± 3.7 | 5.0 ± 4.9 | 0.5 (−1.0 to 2.0) | 0.504 |
Maximal muscle strength (kPa) | (N = 46) | (N = 35) | (N = 50) | |
Handgrip | 33.3 ± 15 | 29.7 ± 18.7 | −0.2 (−2.9 to 2.6) | 0.895 |
Knee flexion | 12.5 ± 3.6 | 12.9 ± 4.2 | 0.4 (−1.0 to 1.8) | 0.564 |
Knee extension | 14.8 ± 4.8 | 15.8 ± 5.0 | 0.8 (−1.1 to 2.8) | 0.392 |
Ankle dorsiflexion | 19.2 ± 6.7 | 20.7 ± 7.4 | 1.4 (−1.1 to 3.8) | 0.254 |
Ankle plantar flexion | 18.7 ± 8.0 | 18.2 ± 6.6 | −0.7 (−3.3 to 1.8) | 0.553 |