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Table 3 Determination of Fracture Risk Assessment (FRAX) score cut-off points for screening for frailty using Area under the Receiver Operating Characteristic (AUROC) curves using sensitivity and specificity measures

From: The association between a fracture risk tool and frailty: Geelong Osteoporosis Study

FRAX scores

Area under the ROC curve (95% CI)

Cut point (Decile)

% Cut point for fracture risk a

Sensitivity

Specificity

Predictive Value (%)

Positive Likelihood ratio (LR+)

Negative Likelihood ratio (LR-)

Women

MOFbwith BMDc

0.72 (0.63–0.80)

5

1.50 (1.06,1.94)

80.0%

45.7%

50.8

1.47

0.44

MOF without BMD

0.71 (0.62–0.79)

5

1.60 (1.21,1.99)

82.2%

45.0%

50.5

1.50

0.40

Hip with BMD

0.69 (0.60–0.78)

5

0.10 (0.00,0.38)

84.4%

30.2%

38.3

1.21

0.51

Hip without BMD

0.68 (0.60–0.77)

5

0.20 (0.02,0.38)

75.6%

49.2%

53.1

1.49

0.50

Men

Hip without BMD

0.76 (0.68–0.82)

5

0.30 (0.12,1.94)

89.6%

45.7%

52.6

1.64

0.23

MOF without BMD

0.73 (0.66–0.80)

5

1.65 (1.36,1.94)

87.5%

47.7%

54.0

1.67

0.26

MOF with BMD

0.68 (0.60–0.76)

5

1.70 (1.45,1.95)

79.2%

46.5%

51.6

1.48

0.45

Hip with BMD

0.67 (0.59–0.75)

5

0.20 (0.05,0.35)

81.3%

44.1%

50.0

1.45

0.42

  1. aReported as median (95% CI) fracture risk percentage
  2. bMOF Major Osteoporotic fractures
  3. cBMD Bone mineral density