Table 6 Association between Baseline Slow Gait Speed and Falls at 18 Months in Mild to Moderate AD. Under all models, slow gait speed was significantly associated with falls (dependent variable) risk at 18 months. ADAS-Cog = Alzheimer Disease Assessment Scale – Cognitive Subsection

IRR (95% CI)

P

IRR (95% CI)

P

IRR (95% CI)

P

Baseline Slow Gait Speed

3.18 (1.97–5.11)

< 0.001

3.27 (1.96–5.50)

< 0.001*

3.09 (1.82–5.22)

< 0.001*

Baseline ADAS-Cog

0.95 (0.92–0.97)

0.001*

0.95 (0.92–0.98)

0.001*

Age

1.07 (1.04–1.10)

< 0.001*

1.07 (1.03–1.10)

< 0.001*

Gender (Female)

1.90 (1.15–3.11)

0.012*

1.60 (0.97–2.65)

0.068

Study Arm

1.20 (0.78–1.83)

0.409

1.32 (0.85–2.06)

0.218

Body Mass Index

0.98 (0.94, 1.03)

0.489

0.96 (0.92–1.01)

0.149

Education (Years)

1.07 (1.01–1.12)

0.021*

1.10 (1.04–1.15)

0.001*

Diagnosis Duration

1.02 (0.88–1.17)

0.816

0.96 (0.84–1.11)

0.612

Total Comorbidities

0.97 (0.88–1.07)

0.527

Diabetes Mellitus

1.73 (0.85–3.51)

0.128

Arthritis

2.19 (1.19–4.04)

0.012*

Total Medications

1.03 (0.95–1.12)

0.490

Benzodiazepine Use

1.05 (1.04–3.64)

0.036*

Antidepressant Use

0.67 (0.41–1.07)

0.096