Table 4 Association between Baseline Cognition (ADAS-Cog) and incident Slow Gait Speed at 18 Months in Mild to Moderate AD. Under all models, baseline cognition was significantly associated with incident slow gait speed (dependent). ADAS-Cog = Alzheimer Disease Assessment Scale – Cognitive Subsection

OR (95% CI)

P

OR (95% CI)

P

OR (95% CI)

P

Baseline ADAS-Cog

1.04 (1.01, 1.07)

0.015*

1.04 (1.01–1.08)

0.009*

1.04 (1.01–1.08)

0.011*

Age

1.10 (1.05–1.15)

< 0.001*

1.10 (1.05–1.16)

< 0.001*

Gender (Female)

0.61 (0.32–1.18)

0.143

0.63 (0.32–1.24)

0.178

Study Arm

0.82 (0.44–1.54)

0.534

0.70 (0.37–1.36)

0.294

Body Mass Index

1.09 (1.01, 1.16)

0.023*

1.10 (1.02, 1.18)

0.014*

Education (Years)

1.08 (0.99–1.16)

0.076

1.08 (0.99–1.17)

0.064

Diagnosis Duration

1.07 (0.90–1.26)

0.443

1.07 (0.90–1.26)

0.466

Total Comorbidities

0.96 (0.82–1.11)

0.531

Diabetes Mellitus

0.41 (0.11–1.59)

0.195

Arthritis

0.54 (0.14–2.10)

0.373

Total Medications

1.06 (0.94–1.21)

0.330

Benzodiazepine Use

1.49 (0.55–4.01)

0.433

Antidepressant Use

0.99 (0.49–1.98)

0.989