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Table 3 Multivariate Cox proportional hazards regression analyses for the risk of dementia after excluding those who were diagnosed within 2, 3, or 4 years among patients with lower urinary tract symptom prescribed with different cumulative defined daily doses of therapeutic bladder anticholinergics

From: Cumulative use of therapeutic bladder anticholinergics and the risk of dementia in patients with lower urinary tract symptoms: a nationwide 12-year cohort study

 

Excluding diagnosis within two yearsa

Excluding diagnosis within three yearsa

Excluding diagnosis within four yearsa

Events (%)

HR

(95% CI)

P

Events (%)

HR

(95% CI)

P

Events (%)

HR

(95% CI)

P

cDDD category

  < 28

1017 (7.4)

1.00

  

861 (6.3)

1.00

  

721 (5.3)

1.00

  

 28–84

98 (7.6)

1.00

(0.82–1.22)

0.995

92 (7.2)

1.06

(0.86–1.31)

0.568

83 (6.5)

1.15

(0.92–1.43)

0.223

 85–336

100 (9.8)

1.30

(1.07–1.59)

0.009

90 (8.8)

1.33

(1.07–1.65)

0.009

77 (7.5)

1.36

(1.08–1.71)

0.008

  ≥ 337

54 (12.8)

1.69

(1.33–2.15)

< 0.001

50 (11.8)

1.77

(1.39–2.26)

< 0.001

44 (10.4)

1.88

(1.44–2.46)

< 0.001

  1. aAdjusted for patient’s age, sex, catastrophic illness certificates, comorbidities, and number of outpatient visits
  2. cDDDs Cumulative defined daily doses, CI Confidence interval, HR Hazard ratio.