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Table 3 Results of the cognitive tests in relation to two and four groups based on eGFR

From: Impaired kidney function is associated with lower cognitive function in the elder general population. Results from the Good Aging in Skåne (GÅS) cohort study

(A) Kidney function by two groups
Cognitive testCognitive domainNumber of participantsMean test resultsB-coefficient95% CI for Bp-value
MMSEGlobal240226.86− 0.411− 0.682, 0.1400.003
Digit span forwardLearning and memory23796.28−0.037− 0.232, 0.1580.708
Free recallLearning and memory23296.64−0.239−0.482, 0.0050.054
RecognitionLearning and memory229911.56−0.562−0.900, − 0.2240.001
Word fluencyLanguage237611.94−0.663−1.148, − 0.1790.007
Digit cancellationComplex attention231916.77−0.45−0.869, − 0.0310.035
Pattern comparisonComplex attention229026.14−0.988−1.697, − 0.2790.006
TMT B-AExecutive function183618.083.7071.539, 5.8740.001
Digit span backwardsExecutive function23735.33−0.159−0.365, 0.0470.131
Mental rotationsPerceptual-motor22620.6−0.001−0.021, 0.0190.91
Confidence judgementMeta-memory23430.110.003−0.006, 0.0120.546
(B) Kidney function by four groups
Cognitive testCognitive domainNumber of participantseGFR level compared to eGFR ≥60 mL/min/1.73 m2 as a referenceB-coefficient95% CI for Bp-value
MMSEGlobal2402< 30
30- < 45
45- < 60
−0.788
−0.776
−0.246
−1.412, − 0.164
−1.173, − 0.379
− 0.538, 0.046
0.013
< 0.001
0.099
Digit span forwardLearning and memory2379< 30
30- < 45
45- < 60
− 0.119
− 0.112
− 0.003
− 0.569, 0.331
− 0.400, 0.175
− 0.214, 0.207
0.603
0.444
0.976
Free recallLearning and memory2329< 30
30- < 45
45- < 60
−0.341
− 0.436
− 0.162
−0.925, 0.243
− 0.798, − 0.075
− 0.425, 0.101
0.252
0.018
0.226
RecognitionLearning and memory2299< 30
30- < 45
45- < 60
− 0.985
− 0.809
− 0.433
− 1.790, − 0.179
− 1.312, − 0.306
− 0.799, − 0.066
0.017
0.002
0.021
Word fluencyLanguage2376< 30
30- < 45
45- < 60
−0.533
− 0.832
− 0.620
−1.675, 0.610
− 1.542, − 0.121
− 1.143, − 0.097
0.361
0.022
0.020
Digit cancellationComplex attention2319< 30
30- < 45
45- < 60
−0.307
− 0.744
− 0.371
− 1.321, 0.706
− 1.375, − 0.112
− 0.823, 0.081
0.553
0.021
0.108
Pattern comparisonComplex attention2290< 30
30- < 45
45- < 60
−0.577
−2.121
− 0.672
−2.303, 1.148
−3.194, − 1.048
− 1.435, 0.091
0.512
< 0.001
0.084
TMT B-AExecutive function1836< 30
30- < 45
45- < 60
2.479
4.993
3.423
−3.202, 8.161
1.612, 8.373
1.081, 5.765
0.392
0.004
0.004
Digit span backwardsExecutive function2373< 30
30- < 45
45- < 60
−0.303
− 0.309
− 0.094
−0.777, 0.172
− 0.614, − 0.004
− 0.317, 0.128
0.211
0.047
0.404
Mental rotationsPerceptual-motor2262< 30
30- < 45
45- < 60
0.016
− 0.003
− 0.002
−0.033, 0.065
− 0.033, 0.027
− 0.024, 0.019
0.530
0.840
0.845
Confidence judgementMeta-memory2343< 30
30- < 45
45- < 60
0.003
0.004
0.002
−0.019, 0.024
− 0.010, 0.017
− 0.007, 0.012
0.796
0.572
0.628
  1. Multiple linear regression models of cognitive tests in relation to kidney function, (A) divided into two groups, impaired kidney function (eGFR < 60 mL/min/1.73 m2) and normal kidney function (eGFR ≥60 mL/min/1.73 m2), with eGFR ≥60 mL/min/1.73 m2 as reference, (B) divided into four groups, severely impaired (eGFR < 30 mL/min/1.73 m2), moderately impaired (eGFR 30- < 45 mL/min/1.73 m2), mildly impaired (eGFR 45- < 60 mL/min/1.73 m2), and normal kidney function (eGFR ≥60 mL/min/1.73 m2), with eGFR ≥60 mL/min/1.73 m2 as reference
  2. All analyses were adjusted for age, sex, education and country of origin
  3. Abbreviations: eGFR estimated glomerular filtration rate, CI Confidence interval