(A) Kidney function by two groups | ||||||
Cognitive test | Cognitive domain | Number of participants | Mean test results | B-coefficient | 95% CI for B | p-value |
MMSE | Global | 2402 | 26.86 | − 0.411 | − 0.682, 0.140 | 0.003 |
Digit span forward | Learning and memory | 2379 | 6.28 | −0.037 | − 0.232, 0.158 | 0.708 |
Free recall | Learning and memory | 2329 | 6.64 | −0.239 | −0.482, 0.005 | 0.054 |
Recognition | Learning and memory | 2299 | 11.56 | −0.562 | −0.900, − 0.224 | 0.001 |
Word fluency | Language | 2376 | 11.94 | −0.663 | −1.148, − 0.179 | 0.007 |
Digit cancellation | Complex attention | 2319 | 16.77 | −0.45 | −0.869, − 0.031 | 0.035 |
Pattern comparison | Complex attention | 2290 | 26.14 | −0.988 | −1.697, − 0.279 | 0.006 |
TMT B-A | Executive function | 1836 | 18.08 | 3.707 | 1.539, 5.874 | 0.001 |
Digit span backwards | Executive function | 2373 | 5.33 | −0.159 | −0.365, 0.047 | 0.131 |
Mental rotations | Perceptual-motor | 2262 | 0.6 | −0.001 | −0.021, 0.019 | 0.91 |
Confidence judgement | Meta-memory | 2343 | 0.11 | 0.003 | −0.006, 0.012 | 0.546 |
(B) Kidney function by four groups | ||||||
Cognitive test | Cognitive domain | Number of participants | eGFR level compared to eGFR ≥60 mL/min/1.73 m2 as a reference | B-coefficient | 95% CI for B | p-value |
MMSE | Global | 2402 | < 30 30- < 45 45- < 60 | −0.788 −0.776 −0.246 | −1.412, − 0.164 −1.173, − 0.379 − 0.538, 0.046 | 0.013 < 0.001 0.099 |
Digit span forward | Learning and memory | 2379 | < 30 30- < 45 45- < 60 | − 0.119 − 0.112 − 0.003 | − 0.569, 0.331 − 0.400, 0.175 − 0.214, 0.207 | 0.603 0.444 0.976 |
Free recall | Learning and memory | 2329 | < 30 30- < 45 45- < 60 | −0.341 − 0.436 − 0.162 | −0.925, 0.243 − 0.798, − 0.075 − 0.425, 0.101 | 0.252 0.018 0.226 |
Recognition | Learning and memory | 2299 | < 30 30- < 45 45- < 60 | − 0.985 − 0.809 − 0.433 | − 1.790, − 0.179 − 1.312, − 0.306 − 0.799, − 0.066 | 0.017 0.002 0.021 |
Word fluency | Language | 2376 | < 30 30- < 45 45- < 60 | −0.533 − 0.832 − 0.620 | −1.675, 0.610 − 1.542, − 0.121 − 1.143, − 0.097 | 0.361 0.022 0.020 |
Digit cancellation | Complex attention | 2319 | < 30 30- < 45 45- < 60 | −0.307 − 0.744 − 0.371 | − 1.321, 0.706 − 1.375, − 0.112 − 0.823, 0.081 | 0.553 0.021 0.108 |
Pattern comparison | Complex attention | 2290 | < 30 30- < 45 45- < 60 | −0.577 −2.121 − 0.672 | −2.303, 1.148 −3.194, − 1.048 − 1.435, 0.091 | 0.512 < 0.001 0.084 |
TMT B-A | Executive function | 1836 | < 30 30- < 45 45- < 60 | 2.479 4.993 3.423 | −3.202, 8.161 1.612, 8.373 1.081, 5.765 | 0.392 0.004 0.004 |
Digit span backwards | Executive function | 2373 | < 30 30- < 45 45- < 60 | −0.303 − 0.309 − 0.094 | −0.777, 0.172 − 0.614, − 0.004 − 0.317, 0.128 | 0.211 0.047 0.404 |
Mental rotations | Perceptual-motor | 2262 | < 30 30- < 45 45- < 60 | 0.016 − 0.003 − 0.002 | −0.033, 0.065 − 0.033, 0.027 − 0.024, 0.019 | 0.530 0.840 0.845 |
Confidence judgement | Meta-memory | 2343 | < 30 30- < 45 45- < 60 | 0.003 0.004 0.002 | −0.019, 0.024 − 0.010, 0.017 − 0.007, 0.012 | 0.796 0.572 0.628 |