Cognitive test | Cognitive domain | Number of0020participants by eGFR | Test result by eGFR | Mean difference | 95% CI of difference | P-value |
---|
(2-tailed) |
---|
| | eGFR < 60 mL/min/1.73 m2 | eGFR ≥60 mL/min/1.73 m2 | eGFR < 60 mL/min/1.73 m2 | eGFR ≥60 mL/min/1.73 m2 | | Lower | Upper | |
MMSE | Global | 778 | 1624 | 25.84 ± 3.08 | 27.34 ± 2.32 | −1.5 | − 1.74 | −1.25 | < 0.001 |
Digit span forward | Learning and memory | 763 | 1616 | 5.95 ± 1.74 | 6.44 ± 1.86 | −0.48 | − 0.63 | − 0.33 | < 0.001 |
Free recall | Learning and memory | 734 | 1595 | 5.77 ± 2.30 | 7.05 ± 2.35 | − 1.28 | − 1.48 | − 1.07 | < 0.001 |
Recognition | Learning and memory | 711 | 1588 | 10.85 ± 3.49 | 11.88 ± 2.81 | −1.03 | − 1.32 | − 0.74 | < 0.001 |
Word fluency | Language | 765 | 1611 | 10.73 ± 4.58 | 12.51 ± 4.93 | −1.77 | −2.18 | − 1.37 | < 0.001 |
Digit cancellation | Complex attention | 711 | 1608 | 14.56 ± 4.17 | 17.75 ± 4.01 | −3.18 | −3.54 | −2.83 | < 0.001 |
Pattern comparison | Complex attention | 692 | 1598 | 21.33 ± 7.20 | 28.22 ± 7.36 | −6.9 | −7.55 | −6.25 | < 0.001 |
TMT B-A | Executive function | 499 | 1337 | 26.00 ± 23.38 | 15.12 ± 14.41 | 10.88 | 8.69 | 13.08 | < 0.001 |
Digit span backwards | Executive function | 760 | 1613 | 4.87 ± 1.84 | 5.54 ± 1.97 | − 0.67 | − 0.83 | − 0.5 | < 0.001 |
Mental rotations | Perceptual-motor | 682 | 1580 | 0.56 ± 0.17 | 0.62 ± 0.19 | − 0.06 | − 0.07 | − 0.04 | < 0.001 |
Confidence judgement | Meta-memory | 749 | 1594 | 0.11 ± 0.08 | 0.11 ± 0.08 | − 0,005 | − 0.01 | 0,002 | 0.185 |
- Results of the cognitive tests in relation to impaired kidney function (eGFR < 60 mL/min/1.73 m2) and normal kidney function (eGFR ≥60 mL/min/1.73 m2)
- Some participants did not participate in all of the cognitive tests. Every participant performed at least one of the cognitive tests
- Equal variances assumed for free recall, digit cancellation, pattern comparison and confidence judgement
- Equal variances not assumed for MMSE, digit span forward, recognition, word fluency, TMT B-A, digit span backwards and mental rotations
- Values following ± represent SD
- Abbreviations: eGFR estimated glomerular filtration rate, CI Confidence interval, SD Standard deviation