From: Characteristics of febrile urinary tract infections in older male adults
Characteristicsa | All patients (nā=ā552) | Older (nā=ā329) | Non-older (nā=ā223) | P value |
---|---|---|---|---|
Baseline conditions | ||||
āAge (years) | 66.1Ā +Ā 16.7 | 77.3Ā +Ā 7.6 | 49.5Ā +Ā 12.2 | <ā 0.001 |
āHCA-FUTI | 203 (36.8) | 177 (53.8) | 26 (11.7)s | <ā 0.001 |
āāPrevious hospital admission | 130 (23.6) | 114 (34.7) | 16 (7.2) | <ā 0.001 |
āāLong term care facility | 46 (8.3) | 43 (13.1) | 3 (1.3) | <ā 0.001 |
āāIV home-day hospital treatment | 13 (2.4) | 9 (2.7) | 4 (1.8) | 0.47 |
āāSpecialized nursing care | 7 (1.3) | 6 (1.8) | 1 (0.4) | 0.25 |
āāIndwelling urinary catheter | 76 (13.8) | 66 (20.1) | 10 (4.5) | <ā 0.001 |
āāāLong-term IUC | 40 (7.2) | 33 (10) | 7 (3.1) | 0.002 |
āāāShort- term IUC | 36 (6.5) | 33 (10) | 3 (1.3) | <ā 0.001 |
āāInvasive urinary intrumentation | 110 (19.9) | 98 (29.8) | 12 (5.4) | <ā 0.001 |
āDementia | 64 (11.6) | 62 (18.8) | 2 (0.9) | <ā 0.001 |
āDiabetes mellitus | 148 (26.8) | 113 (34.3) | 35 (15.7) | <ā 0.001 |
āChronic kidney failure | 54 (9.8) | 49 (14.9) | 5 (2.2) | <ā 0.001 |
āCirrhosis | 9 (1.6) | 5 (1.5) | 4 (1.8) | 1 |
āNeoplasia | 81 (14.7) | 72 (21.9) | 9 (4) | <ā 0.001 |
āHeart failure | 8 (1.4) | 7 (2.1) | 1 (0.4) | 0.15 |
āChronic obstructive lung disease | 100 (18.1) | 90 (27.4) | 10 (4.5) | <ā 0.01 |
āImmunosuppressive or corticosteroid treatment | 11 (2) | 7 (2.1) | 4 (1.8) | 1 |
āCharlson score | 3.6Ā +Ā 2.5 | 5.1Ā +Ā 1.7 | 1.3Ā +Ā 1.6 | <ā 0.001 |
āPrevious UTI | 222 (45.5) | 152 (53.7) | 70 (34.1) | <ā 0.001 |
āUrinary tract abnormality | 339 (61.5) | 252 (76.8) | 87 (39) | <ā 0.001 |
āāBPH | 239 (43.4) | 187 (57) | 52 (23.3) | <ā 0.001 |
āāUrogenital cancer | 48 (8.8) | 44 (13.6) | 4 (1.8) | <ā 0.001 |
āPrevious antibiotic treatment | 179 (32.6) | 135 (41.3) | 44 (19.8) | <ā 0.001 |
āāAminopenicillins | 60 (11) | 42 (13) | 18 (8.2) | 0.081 |
āāFluoroquinolones | 54 (9.9) | 41 (12.7) | 13 (5.9) | 0.010 |
āāTGC | 16 (2.9) | 11 (3.4) | 5 (2.3) | 0.44 |
āāFosfomycine | 10 (1.8) | 9 (2.8) | 1 (0.5) | 0.055 |
Clinical presentation | ||||
āLUTS | 359 (65.3) | 172 (52.4) | 187 (84.2) | <ā 0.001 |
āFlank pain | 89 (16.2) | 31 (9.5) | 58 (26.1) | <ā 0.001 |
Physical examination | ||||
āTemperature | 37.7Ā +Ā 1 | 37.7Ā +Ā 1.1 | 37.7Ā +Ā 0.9 | 0.85 |
āMAP (mmHg) | 93.4Ā +Ā 15.3 | 91.1Ā +Ā 15.3 | 96.9Ā +Ā 14.7 | <ā 0.001 |
āLumbar tenderness | 94 (22.1) | 40 (17.3) | 54 (27.7) | 0.010 |
āProstatic tenderness | 81 (42.6) | 35 (37.2) | 46 (47.9) | 0.13 |
Laboratory | ||||
āWBC count (leukocytes/mm3) | 13,903Ā +Ā 5743 | 13,348Ā +Ā 5536 | 14,759Ā +Ā 5961 | 0.006 |
āCreatinine (mg/dl) | 1.2Ā +Ā 0.7 | 1.4Ā +Ā 0.8 | 1.1Ā +Ā 0.4 | <ā 0.010 |
āBacteremia | 120 (31.6) | 92 (38) | 28 (20.3) | <ā 0.010 |
Treatment | ||||
āEmpirical treatment with TGC | 307 (55.6) | 176 (53.5) | 131 (58.7) | 0.22 |
āEmpirical treatment with carbapenems or PT | 59 (10.7) | 46 (14) | 13 (5.8) | 0.002 |
āIEAT | 95 (17.2) | 69 (21) | 26 (11.7) | 0.004 |
āOPAT | 71 (12.9) | 54 (16.4) | 17 (7.6) | 0.002 |
Outcomes | ||||
āSevere sepsis or septic shock | 17 (3.1) | 12 (3.6) | 5 (2.2) | 0.35 |
āHospital admission | 266 (48.2) | 197 (59.9) | 69 (30.9) | <ā 0.001 |
āLength of hospitalisation (days) | 2.6Ā +Ā 4.1 | 3.3Ā +Ā 4.6 | 1.4Ā +Ā 2.9 | <ā 0.001 |
āLength antimicrobial therapy (days) | 16.3Ā +Ā 6.7 | 16Ā +Ā 7 | 16.8Ā +Ā 6.5 | 0.19 |
āAll-cause in-hospital mortality | 15 (2.7) | 14 (4.3) | 1 (0.4) | 0.007 |
āAttributable in-hospital mortality | 8 (1.4) | 8 (2.4) | 0 | 0.024 |