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Table 2 Univariate and multivariate analyses of outcomes in the ≥75-year-old group

From: Predictors of clinical outcomes after cardiac resynchronization therapy in patients ≥75 years of age: a retrospective cohort study

 Univariate analysisMultivariate analysis
(model 1 with atrial fibrillation)
Multivariate analysis
(model 2 with anticoagulation)
OR (95% CI)p valueOR (95% CI)p valueOR (95% CI)p value
Primary endpoint
NYHA ≥III5.91 (2.02–17.30)0.0016.02 (1.33–18.77)0.0026.30 (2.04–19.67)0.001
Rescue CRT0.49 (0.40–0.60)0.01    
CKD0.41 (0.16–1.03)0.06    
Loop diuretics0.32 (0.09–1.11)0.06    
Anticoagulation0.51 (0.23–1.15)0.10    
Atrial fibrillation0.51 (0.23–1.15)0.10    
ACEI-ARB2.07 (0.84–5.11)0.112.55 (0.91–7.11))0.072.38 (0.87–6.49)0.09
Surgery duration1.87 (0.85–4.11)0.12    
QRS = 130–150 ms0.50 (0.20–1.27)0.14    
One-year mortality
Rescue CRT58.8 (6.55–528-28)< 0.00144.67 (2.91–686)0.0163.28 (4.47–896)0.002
CRT-D0.23 (0.07–0.75)0.01    
Atrial fibrillation4.03 (1.07–15.20)0.036.72 (0.99–45.61)0.04  
QRS > 150 ms2.64 (0.86–8.15)0.083.79 (0.79–18.21)0.10  
Surgery duration0.39 (0.13–1.2)0.090.11 (0.02–0.63)0.010.14 (0.03–0.76)0.02
CKD3.54 (0.75–16.67)0.09    
Upgrade0.36 (0.08–1.69)0.10    
Anticoagulation2.43 (0.72–8.13)0.14    
Beta-blockers0.42 (0.12–1.42)0.15    
Ivabradine2.63 (0.60–11.41)0.189.99 (1.17–85.42)0.046.36 (1.10–36.90)0.04
ACEI-ARB0.47 (0.15–1.49)0.19    
  1. Anticoagulation and atrial fibrillation were significantly correlated in the ≥75-year-old group (Pearson coefficient 0.79, p < 0.001). We performed two different regression models if the p values were both < 0.2 in the univariate analysis. We reported here variables with p values ≤0.2 in the univariate analysis and ≤ 0.10 in the multivariate analysis. ACEI: angiotensin-converting enzyme inhibitor; ARB: angiotensin II receptor blocker; CKD: chronic kidney disease (defined by estimated glomerular filtration < 60 ml/mn/1.73 m2); CRT: cardiac resynchronization therapy; CRT-D: CRT with defibrillator; NYHA: New York Heart Association
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