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Table 2 Univariate and multivariate analyses of outcomes in the ≥75-year-old group

From: Predictors of clinical outcomes after cardiac resynchronization therapy in patients ≥75 years of age: a retrospective cohort study

 

Univariate analysis

Multivariate analysis

(model 1 with atrial fibrillation)

Multivariate analysis

(model 2 with anticoagulation)

OR (95% CI)

p value

OR (95% CI)

p value

OR (95% CI)

p value

Primary endpoint

NYHA ≥III

5.91 (2.02–17.30)

0.001

6.02 (1.33–18.77)

0.002

6.30 (2.04–19.67)

0.001

Rescue CRT

0.49 (0.40–0.60)

0.01

    

CKD

0.41 (0.16–1.03)

0.06

    

Loop diuretics

0.32 (0.09–1.11)

0.06

    

Anticoagulation

0.51 (0.23–1.15)

0.10

    

Atrial fibrillation

0.51 (0.23–1.15)

0.10

    

ACEI-ARB

2.07 (0.84–5.11)

0.11

2.55 (0.91–7.11))

0.07

2.38 (0.87–6.49)

0.09

Surgery duration

1.87 (0.85–4.11)

0.12

    

QRS = 130–150 ms

0.50 (0.20–1.27)

0.14

    

One-year mortality

Rescue CRT

58.8 (6.55–528-28)

< 0.001

44.67 (2.91–686)

0.01

63.28 (4.47–896)

0.002

CRT-D

0.23 (0.07–0.75)

0.01

    

Atrial fibrillation

4.03 (1.07–15.20)

0.03

6.72 (0.99–45.61)

0.04

  

QRS > 150 ms

2.64 (0.86–8.15)

0.08

3.79 (0.79–18.21)

0.10

  

Surgery duration

0.39 (0.13–1.2)

0.09

0.11 (0.02–0.63)

0.01

0.14 (0.03–0.76)

0.02

CKD

3.54 (0.75–16.67)

0.09

    

Upgrade

0.36 (0.08–1.69)

0.10

    

Anticoagulation

2.43 (0.72–8.13)

0.14

    

Beta-blockers

0.42 (0.12–1.42)

0.15

    

Ivabradine

2.63 (0.60–11.41)

0.18

9.99 (1.17–85.42)

0.04

6.36 (1.10–36.90)

0.04

ACEI-ARB

0.47 (0.15–1.49)

0.19

    
  1. Anticoagulation and atrial fibrillation were significantly correlated in the ≥75-year-old group (Pearson coefficient 0.79, p < 0.001). We performed two different regression models if the p values were both < 0.2 in the univariate analysis. We reported here variables with p values ≤0.2 in the univariate analysis and ≤ 0.10 in the multivariate analysis. ACEI: angiotensin-converting enzyme inhibitor; ARB: angiotensin II receptor blocker; CKD: chronic kidney disease (defined by estimated glomerular filtration < 60 ml/mn/1.73 m2); CRT: cardiac resynchronization therapy; CRT-D: CRT with defibrillator; NYHA: New York Heart Association