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Table 2 Parameter estimates, Standard Errors and p values from adjusted linear mixed regression models for episodic memory scores

From: Cardiovascular risk factors and memory decline in middle-aged and older adults: the English Longitudinal Study of Ageing

 

Unadjusted models

Adjusted models

Parameter

Categories

Middle-aged

Older adults

Middle-aged

Older people

Estimation

SE

p

Estimation

SE

p

Estimation

SE

p

Estimation

SE

p

Intercept

       

8.384

0.220

<.0001

6.60

0.311

<.0001

Time (per year)

 

0.010

0.005

.039

−0.115

0.007

<.0001

0.040

0.011

.001

−0.096

0.019

<.0001

CVRFs

None

Ref.

  

Ref.

  

Ref.

  

Ref.

  

One

−0.470

0.105

<.0001

−0.376

0.161

.020

− 0.056

0.106

0.599

0.139

0.157

0.378

Two

−1.101

0.115

<.0001

−0.792

0.166

<.0001

− 0.245

0.118

0.038

0.111

0.164

0.498

Three or more

−1.463

0.131

<.0001

−1.414

0.174

<.0001

−0.241

0.137

0.080

−0.194

0.175

0.268

Age (centred)

 

−0.132

0.009

<.0001

−0.197

0.012

<.0001

−0.110

0.008

<.0001

−0.153

0.011

<.0001

CES-D

 

−0.248

0.019

<.0001

−0.246

0.027

<.0001

−0.149

0.018

<.0001

−0.119

0.025

<.0001

Missing-data pattern

Non-completers

Ref.

  

Ref.

  

Ref.

  

Ref.

  

Completers

0.961

0.077

<.0001

1.602

0.097

<.0001

0.550

0.069

<.0001

1.090

0.091

<.0001

Wealth

1-quintile (lowest)

Ref.

  

Ref.

  

Ref.

  

Ref.

  

2-quintile

0.641

0.076

<.0001

0.849

0.156

<.0001

0.221

0.121

.068

0.515

0.143

<.0001

3-quintile

1.265

0.128

<.0001

1.340

0.155

<.0001

0.532

0.123

<.0001

0.780

0.146

<.0001

4-quintile

1.761

0.126

<.0001

1.728

0.153

<.0001

0.746

0.124

<.0001

0.875

0.150

<.0001

5-quintile (highest)

2.105

0.124

<.0001

2.476

0.155

<.0001

0.973

0.128

<.0001

1.371

0.159

<.0001

Gender

Males

Ref.

  

Ref.

  

Ref.

  

Ref.

  

Female

0.668

0.076

<.0001

0.612

0.101

<.0001

0.863

0.069

<.0001

0.855

0.094

<.0001

Education level

Low

Ref.

  

Ref.

  

Ref.

  

Ref.

  

Medium

1.470

0.090

<.0001

1.375

0.113

<.0001

1.034

0.087

<.0001

0.964

0.106

<.0001

High

2.267

0.087

<.0001

2.055

0.122

<.0001

1.711

0.090

<.0001

1.443

0.122

<.0001

Marital status

Never married

Ref.

  

Ref.

  

Ref.

  

Ref.

  

Married/remarried

0.555

0.167

.001

0.885

0.245

<.0001

0.255

0.146

.082

0.353

0.214

.099

Legally separated or divorced

0.262

0.190

0.167

0.733

0.297

0.014

0.295

0.166

.075

0.434

0.258

.092

Widowed

0.013

0.229

0.954

0.524

0.259

0.043

0.202

0.202

.316

0.560

0.226

.013

Non-CVDs

None

Ref.

  

Ref.

  

Ref.

  

Ref.

  

One

−0.250

0.085

.003

0.017

0.109

0.875

0.050

0.075

.506

0.156

0.096

.106

Two or more

−0.546

0.135

<.0001

−0.072

0.155

0.641

0.122

0.123

.322

0.348

0.139

.013

CVDs

None

Ref.

  

Ref.

  

Ref.

  

Ref.

  

One

−0.668

0.133

<.0001

−0.363

0.131

<.001

−0.157

0.118

.181

−0.017

0.115

.883

Two or more

−1.289

0.241

<.0001

−0.753

0.198

<.0001

−0.154

0.216

.478

−0.068

0.175

.695

CVRFs*time

None*time

      

Ref.

  

Ref.

  

One*time (per yr)

      

−0.035

0.014

.013

−0.035

0.022

.122

Two*time (per yr)

      

−0.45

0.015

.003

−0.030

0.023

.197

Three or more*time (per yr)

      

−0.061

0.018

.001

−0.027

0.025

.286

Random variance

Intercept

       

3.438

0.186

<.0001

4.101

0.263

<.0001

Linear slope

       

0.062

0.010

<.001

0.122

0.016

<.0001

Residual

       

4.968

0.060

<.001

5.313

0.082

<.0001

  1. Note: In bold, significant effect
  2. SE Standard error, CVRFs Cardiovascular risk factors score, CES-D Centre for Epidemiologic Studies Depression Scale, CVDs Cardiovascular diseases, non-CVDs non cardiovascular diseases
  3. CES-D scores ranged from 0 to 8; Episodic memory scores ranged from 0 to 20; low education level included people with no qualifications