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Table 4 Hazard ratios (95% CI) for three-year all-cause mortality according to sarcopenia definition, muscle mass and body composition, muscle strength and physical performance

From: Sarcopenia prevalence and associations with mortality and hospitalisation by various sarcopenia definitions in 85–89 year old community-dwelling men: a report from the ULSAM study

 

Model 1

HR (95% CI)

p

Model 2

HR (95% CI)

p

Model 3

HR (95% CI)

p

Sarcopenia (EWGSOP)

1.97 (1.14–3.39)

0.015

1.90 (1.10–3.28)

0.021

1.95 (1.12–3.40)

0.019

Probable sarcopenia (EWGSOP2)

3.82 (1.64–8.87)

0.002

3.17 (1.34–7.49)

0.008

3.26 (1.38–7.70)

0.007

Sarcopenia (EWGSOP2)

1.50 (0.84–2.65)

0.17

1.55 (0.87–2.75)

0.14

1.70 (0.94–3.05)

0.078

Sarcopenia (FNIH)

1.96 (0.93–4.13)

0.077

1.62 (0.75–3.50)

0.22

1.65 (0.73–3.72)

0.23

Muscle mass measurements and body composition

 SMIb, kg/m2

0.69 (0.54–0.90)

0.005

0.68 (0.52–0.87)

0.003

0.64 (0.50–0.82)

< 0.001

  < 7.0 kg/m2

1.29 (0.74–2.24)

0.37

1.42 (0.81–2.49)

0.22

1.57 (0.89–2.78)

0.12

  < 7.26 kg/m2

1.73 (1.04–2.88)

0.033

1.77 (1.07–2.94)

0.026

1.94 (1.15–3.28)

0.013

 ASMMb, kg

0.68 (0.53–0.89)

0.004

0.67 (0.51–0.87)

0.003

0.65 (0.50–0.83)

0.001

  < 19.75 kg

2.24 (1.30–3.85)

0.004

2.31 (1.34–3.99)

0.003

2.56 (1.46–4.47)

0.001

  < 20 kg

1.96 (1.15–3.36)

0.014

2.06 (1.20–3.54)

0.009

2.01 (1.17–3.46)

0.012

 ALMbBMI

0.94 (0.72–1.22)

0.64

0.98 (0.76–1.27)

0.88

1.05 (0.81–1.37)

0.69

  < 0.789

1.38 (0.78–2.44)

0.27

1.26 (0.71–2.25)

0.43

1.05 (0.57–1.96)

0.87

 BMIb, kg/m2

0.75 (0.57–0.99)

0.039

0.73 (0.56–0.95)

0.017

0.65 (0.50–0.84)

0.001

 FMbtot, kg

0.90 (0.70–1.17)

0.44

0.86 (0.67–1.10)

0.23

0.79 (0.62–1.01)

0.056

 FMIb, kg/m2

0.94 (0.73–1.21)

0.63

0.88 (0.69–1.14)

0.34

0.80 (0.63–1.02)

0.077

Muscle strength and physical performance

 HGSb, kg

0.61 (0.47–0.80)

< 0.001

0.65 (0.49–0.85)

0.001

0.62 (0.47–0.82)

< 0.001

  < 30 kg

1.97 (1.17–3.33)

0.011

1.83 (1.08–3.11)

0.025

1.87 (1.10–3.18)

0.021

  < 27 kg

1.64 (0.97–2.78)

0.066

1.52 (0.89–2.59)

0.12

1.56 (0.91–2.69)

0.11

  < 26 kg

1.78 (1.03–3.11)

0.040

1.60 (0.91–2.82)

0.10

1.76 (0.97–3.20)

0.062

 GSb, m/s

0.58 (0.45–0.74)

< 0.001

0.62 (0.48–0.81)

< 0.001

0.61 (0.46–0.81)

0.001

  ≤0.8 m/s

2.67 (1.21–5.88)

0.015

2.13 (0.95–4.76)

0.065

2.24 (0.94–5.31)

0.067

  < 0.8 m/s

2.24 (0.89–5.60)

0.085

1.66 (0.65–4.23)

0.29

1.69 (0.62–4.59)

0.30

 CSa, b, sec

1.26 (1.04–1.53)

0.020

1.13 (0.89–1.43)

0.33

1.14 (0.88–1.47)

0.31

  > 15 s

2.77 (1.41–5.48)

0.003

2.28 (1.13–4.61)

0.022

2.44 (1.20–4.94)

0.013

  1. aFor chair stand test n = 244. bContinuous variables are scaled by standard deviation
  2. Cox regression models were used for analyses. Model 1: unadjusted. Model 2: adjusted for age, Charlson index. Model 3: adjusted for age, Charlson index, education, smoking, MMSE
  3. EWGSOP European Working Group on Sarcopenia in Older People [3], EWGSOP2 European Working Group on Sarcopenia in Older People, 2018 update [4], FNIH Foundation for the National Institutes of Health Sarcopenia Project [9], SMI skeletal muscle mass index, ASMM appendicular skeletal muscle mass, ALMBMI appendicular lean mass/BMI, BMI body mass index, FMtot fat mass (total), FMI fat mass index, HGS hand grip strength, GS gait speed, CS chair stand test, MMSE mini mental state exam