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Table 4 Sensitivity analyses of the relationship between Cognitive measures and Anemiaa

From: Association between anemia and cognitive decline among Chinese middle-aged and elderly: evidence from the China health and retirement longitudinal study

MethodsOutcome variableCross-sectional analysesLongitudinal analyses
β (95%CI)p-valueβ (95%CI)p-value
1:4 PSMGlobal Cognition−0.47(− 0.69, − 0.25)< 0.001−0.22(− 0.44, − 0.01)0.038
Episodic Memory−0.14(− 0.24, − 0.05)0.004−0.15(− 0.25, − 0.05)0.003
TICS−0.22(− 0.38, − 0.05)0.009−0.04(− 0.21, 0.12)0.590
80 < MCV < 100Global Cognition−0.48(− 0.71, − 0.24)< 0.001−0.31(− 0.54, − 0.08)0.009
Episodic Memory−0.13(− 0.23, − 0.03)0.014−0.14(− 0.25, − 0.03)0.016
TICS−0.20(− 0.37, − 0.03)0.023−0.10(− 0.27, 0.08)0.266
BMI ≥ 18.5Global Cognition−0.42(− 0.63, − 0.21)< 0.001−0.22(− 0.42, − 0.02)0.030
Episodic Memory−0.13(− 0.22, − 0.04)0.005−0.15(− 0.25, − 0.06)0.002
TICS−0.17(− 0.32, − 0.02)0.031−0.03(− 0.19, 0.12)0.653
  1. BMI Body mass index, MCV Mean corpuscular volume, eGFR Estimated glomerular function rate, CI Confidence interval, PSM Propensity Scoring Matching, TICS Telephone Interview of Cognitive Status
  2. Notes:a Anemia was defined as hemoglobin concentrations lower than 13 g/dl for men and lower than 12 g/dl for women; All sensitivity analyses were conducted with the Cognitive Test Scores as the outcome and the baseline dichotomous anemia as the independent variable; All the analyses were adjusted for age, education level, marital status, BMI, cigarette smoking status, alcohol consumption, C reactive protein, total cholesterol, high density lipoprotein cholesterol, chronic pain, MCV, eGFR and associated comorbidities (cancer, kidney, stroke, heart, lung, hypertension, diabetes);
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